Skip to main content
SpringerLink
Log in

Consider pharmacotherapy for antipsychotic-induced orthostatic hypotension only if nonpharmacological measures fail

  • Drug Reactions and Interactions
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Table I
Table II

References

  1. Gugger JJ. Antipsychotic pharmacotherapy and orthostatic hypotension: identification and management CNS Drugs 2011; 25 (8): 659–71

    CAS  Google Scholar 

  2. Ray WA, Chung CP, Murray KT, et al. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009; 360 (18): 225–35

    Article  PubMed  CAS  Google Scholar 

  3. Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005; 353 (12): 1209–23

    Article  PubMed  CAS  Google Scholar 

  4. Stroup TS, Lieberman JA, McEvoy JP, et al. Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study. Am J Psychiatry 2007; 164 (3): 415–27

    Article  PubMed  Google Scholar 

  5. Stroup TS, Lieberman JA, McEvoy JP, et al. Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. Am J Psychiatry 2006; 163 (4): 611–22

    Article  PubMed  Google Scholar 

  6. McEvoy JP, Lieberman JA, Stroup TS, et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry 2006; 163 (4): 600–10

    Article  PubMed  Google Scholar 

  7. Stroup TS, Lieberman JA, McEvoy JP, et al. Results of phase 3 of the CATIE schizophrenia trial. Schizophr Res 2009; 107 (1): 1–12

    Article  PubMed  Google Scholar 

  8. Weiden PJ, Cutler AJ, Polymeropoulos MH, et al. Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol 2008; 28 (2 Suppl. 1): S12–9

    Article  PubMed  CAS  Google Scholar 

  9. Chandrasena R, Dvorakova D, Lee SI, et al. Intramuscular olanzapine vs. intramuscular short-acting antipsychotics: safety, tolerability and the switch to oral antipsychotic medication in patients with schizophrenia or acute mania. Int J Clin Pract 2009; 63 (8): 1249–58

    Article  PubMed  CAS  Google Scholar 

  10. Ritter RM, Davidson DE, Robinson TA. Comparison of injectable haloperidol and chlorpromazine. Am J Psychiatry 1972; 129 (1): 78–81

    PubMed  CAS  Google Scholar 

  11. Iserson KV. Parenteral chlorpromazine treatment of migraine. Ann Emerg Med 1983; 12 (12): 756–8

    Article  PubMed  CAS  Google Scholar 

  12. LaWall JS. Treatment of psychotropic-caused orthostatic hypotension. Psychosomatics 1980; 21 (8): 693–4

    PubMed  CAS  Google Scholar 

  13. Chengappa KN, Parepally H, Brar JS, et al. A random-assignment, double-blind, clinical trial of once- vs twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder: a pilot study. Can J Psychiatry 2003; 48 (3): 187–94

    PubMed  Google Scholar 

  14. Pae CU, Kim JJ, Lee CU, et al. Rapid versus conventional initiation of quetiapine in the treatment of schizophrenia: a randomized, parallel-group trial. J Clin Psychiatry 2007; 68 (3): 399–405

    Article  PubMed  CAS  Google Scholar 

  15. BoidiG, Ferro M. Rapid dose initiation of quetiapine for the treatment of acute schizophrenia and schizoaffective disorder: a randomised, multicentre, parallel-group, open study. Hum Psychopharmacol 2007; 22 (5): 299–306

    Article  Google Scholar 

  16. Smith MA, McCoy R, Hamer-Maansson J, et al. Rapid dose escalation with quetiapine: a pilot study. J Clin Psychopharmacol 2005; 25 (4): 331–5

    Article  PubMed  CAS  Google Scholar 

  17. Baker RW, Kinon BJ, Maguire GA, et al. Effectiveness of rapid initial dose escalation of up to forty milligrams per day of oral olanzapine in acute agitation. J Clin Psychopharmacol 2003; 23 (4): 342–8

    Article  PubMed  CAS  Google Scholar 

  18. Karagianis JL, Dawe IC, Thakur A, et al. Rapid tranquilization with olanzapine in acute psychosis: a case series. J Clin Psychiatry 2001; 62 Suppl. 2: 12–6

    PubMed  CAS  Google Scholar 

  19. Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry 2000; 61 (12): 909–11

    Article  PubMed  CAS  Google Scholar 

  20. Clozaril® (clozapine) tablets: US prescribing information. East Hanover (NJ): Novartis Pharmaceuticals Corporation, 2011 Oct

  21. Figueroa JJ, Basford JR, Low PA. Preventing and treating orthostatic hypotension: as easy as A, B, C. Cleve Clin J Med 2010; 77 (5): 298–306

    Article  PubMed  Google Scholar 

  22. Freeman R. Current pharmacological treatment for orthostatic hypotension. Clin Auton Res 2008; 18 Suppl. 1: 14–8

    Article  PubMed  Google Scholar 

  23. Kranzler HR, Cardoni A. Sodium chloride treatment of anti-depressant-induced orthostatic hypotension. J Clin Psychiatry 1988; 49 (9): 366–8

    PubMed  CAS  Google Scholar 

  24. Testani Jr M. Clozapine-induced orthostatic hypotension treated with fludrocortisone. J Clin Psychiatry 1994; 55 (11): 497–8

    PubMed  Google Scholar 

  25. Kaufmann H. Treatment of patients with orthostatic hypotension and syncope. Clin Neuropharmacol 2002; 25 (3): 133–41

    Article  PubMed  Google Scholar 

  26. Sarma S, Ward W, O’Brien J, et al. Severe hyponatraemia associated with desmopressin nasal spray to treat clozapine-induced nocturnal enuresis [letter]. Aust N Z J Psychiatry 2005; 39 (10): 949

    Article  PubMed  Google Scholar 

  27. Maskall DD, Lam RW. Midodrine for TCA-induced orthostatic hypotension. J Psychiatry Neurosci 1993; 18 (5): 276–7

    PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Consider pharmacotherapy for antipsychotic-induced orthostatic hypotension only if nonpharmacological measures fail. Drugs Ther Perspect 28, 19–23 (2012). https://doi.org/10.1007/BF03262123

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03262123

Search

Navigation