Henry D, McGettigan P. Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs. Int J Clin Pract Suppl 2003 Apr; (135): 43–9
PubMed
Google Scholar
Hernández-Díaz S, Rodríguez LA. Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s. Arch Intern Med 2000 Jul 24; 160(14): 2093–9
PubMed
Article
Google Scholar
Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study — randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 2000 Sep 13; 284(10): 1247–55
PubMed
CAS
Article
Google Scholar
Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000 Nov 23; 343(21): 1520–8
PubMed
CAS
Article
Google Scholar
Massó González EL, Patrignani P, Tacconelli S, et al. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010 Jun; 62(6): 1592–601
Article
Google Scholar
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT). PLoS Clin Trials 2006; 1(7): e33
García Rodríguez LA, Barreales TL. Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology 2007; 132(2): 498–506
PubMed
Article
Google Scholar
Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa (ON): Ottawa Hospital Research Institute, 2010 [online]. Available from URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford,asp [Accessed 2011 Jun 20]
Google Scholar
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986 Sep; 7(3): 177–88
PubMed
CAS
Article
Google Scholar
Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003 Sep 6; 327(7414): 557–60
PubMed Central
PubMed
Article
Google Scholar
García Rodríguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343(8900): 769–72
PubMed
Article
Google Scholar
Matikainen M, Kangas E. Is there a relationship between the use of analgesics and non-steroidal anti-inflammatory drugs and acute upper gastrointestinal bleeding? A Finnish case-control prospective study. Scand J Gastroenterol 1996 Sep; 31(9): 912–6
PubMed
CAS
Article
Google Scholar
Moride Y, Abenhaim L. Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research. J Clin Epidemiol 1994; 47(7): 731–7
PubMed
CAS
Article
Google Scholar
Biskupiak JE, Brixner DI, Howard K, et al. Gastrointestinal complications of over-the-counter nonsteroidal antiinflammatory drugs. J Pain Palliat Care Pharmacother 2006; 20(3): 7–14
PubMed
Article
Google Scholar
Sakamoto C, Sugano K, Ota S, et al. Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan. Eur J Clin Pharmacol 2006; 62(9): 765–72
PubMed
CAS
Article
Google Scholar
Lanas A, García-Rodríguez LA, Arroyo MT, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. Gut 2006; 55(12): 1731–8
PubMed Central
PubMed
CAS
Article
Google Scholar
Helin-Salmivaara A, Saarelainen S, Grönroos JM, et al. Risk of upper gastrointestinal events with the use of various NSAIDs: a case-control study in a general population. Scand J Gastroenterol 2007; 42(8): 923–32
PubMed
CAS
Article
Google Scholar
Hippisley-Cox J, Coupland C, Logan R. Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ 2005; 331(7528): 1310–6
PubMed Central
PubMed
CAS
Article
Google Scholar
Nørgård B, Pedersen L, Johnsen SP, et al. COX-2-selective inhibitors and the risk of upper gastrointestinal bleeding in high-risk patients with previous gastrointestinal diseases: a population-based case-control study. Aliment Pharmacol Ther 2004; 19(7): 817–25
PubMed
Article
Google Scholar
Mamdani M, Rochon PA, Juurlink DN, et al. Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ 2002; 325(7365): 624
PubMed Central
PubMed
CAS
Article
Google Scholar
Laporte JR, Ibáñez L, Vidal X, et al. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Saf 2004; 27(6): 411–20
PubMed
CAS
Article
Google Scholar
Lanas A, Serrano P, Bajador E, et al. Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs. Eur J Gastroenterol Hepatol 2003 Feb; 15(2): 173–8
PubMed
CAS
Article
Google Scholar
García Rodríguez LA, Hernández-Díaz S. Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology 2001; 12(5): 570–6
PubMed
Article
Google Scholar
Menniti-Ippolito F, Maggini M, Raschetti R, et al. Ketorolac use in outpatients and gastrointestinal hospitalization: a comparison with other non-steroidal anti-inflammatory drugs in Italy. Eur J Clin Pharmacol 1998; 54(5): 393–7
PubMed
CAS
Article
Google Scholar
García Rodríguez LA, Cattaruzzi C, Troncon MG, et al. Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other anti-hypertensive drugs. Arch Intern Med 1998; 158(1): 33–9
PubMed
Article
Google Scholar
McMahon AD, Evans JM, White G, et al. A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation. J Clin Epidemiol 1997; 50(3): 351–6
PubMed
CAS
Article
Google Scholar
Kaufman DW, Kelly JP, Sheehan JE, et al. Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding. Clin Pharmacol Ther 1993; 53(4): 485–94
PubMed
CAS
Article
Google Scholar
Langman MJ, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994; 343(8905): 1075–8
PubMed
CAS
Article
Google Scholar
Nobili A, Mosconi P, Franzoni MG, et al. Non-steroidal anti-inflammatory drugs and upper gastrointestinal bleeding, a post-marketing surveillance case-control study. Pharmacoepidemiol Drug Saf 1992; 1: 65–72
Article
Google Scholar
Laporte JR, Carné X, Vidal X, et al. Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding. Lancet 1991; 337(8733): 85–9
PubMed
CAS
Article
Google Scholar
Savage RL, Moller PW, Ballantyne CL, et al. Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy. Arthritis Rheum 1993; 36(1): 84–90
PubMed
CAS
Article
Google Scholar
Henry D, Dobson A, Turner C. Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology 1993; 105(4): 1078–88
PubMed
CAS
Google Scholar
Griffin MR, Piper JM, Daugherty JR, et al. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114(4): 257–63
PubMed
CAS
Article
Google Scholar
Somerville K, Faulkner G, Langman M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986 Mar 1; 1(8479): 462–4
PubMed
CAS
Article
Google Scholar
Perez-Gutthann S, García-Rodríguez LA, Raiford DS. Individual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology 1997; 8(1): 18–24
Article
Google Scholar
Carson JL, Strom BL, Morse ML, et al. The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs. Arch Intern Med 1987; 147(6): 1054–9
PubMed
CAS
Article
Google Scholar
Strom BL, Schinnar R, Bilker WB, et al. Gastrointestinal tract bleeding associated with naproxen sodium vs ibuprofen. ArchInternMed 1997; 157(22): 2626–31
CAS
Google Scholar
MacDonald TM, Morant SV, Robinson GC, et al. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study. BMJ 1997; 315(7119): 1333–7
PubMed Central
PubMed
CAS
Article
Google Scholar
Perez-Gutthann S, García-Rodríguez LA, Duque-Oliart A, et al. Low-dose diclofenac, naproxen, and ibuprofen cohort study. Pharmacotherapy 1999; 19(7): 854–9
PubMed
CAS
Article
Google Scholar
Ashworth NL, Peloso PM, Muhajarine N, et al. Risk of hospitalization with peptic ulcer disease or gastrointestinal hemorrhage associated with nabumetone, arthrotec, diclofenac, and naproxen in a population based cohort study. J Rheumatol 2005; 32(11): 2212–7
PubMed
CAS
Google Scholar
Patterson MK, Castellsague J, Walker AM. Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib. Pharmacoepidemiol Drug Saf 2008 Oct; 17(10): 982–8
PubMed
Article
Google Scholar
Ray WA, Chung CP, Stein CM, et al. Risk of peptic ulcer hospitalizations in users of NSAIDs with gastroprotective cotherapy versus coxibs. Gastroenterology 2007; 133(3): 790–8
PubMed
CAS
Article
Google Scholar
Rahme E, Bardou M, Dasgupta K, et al. Hospitalization for gastrointestinal bleeding associated with non-steroidal anti-inflammatory drugs among elderly patients using low-dose aspirin: a retrospective cohort study. Rheumatology (Oxford) 2007; 46(2): 265–72
CAS
Article
Google Scholar
Rahme E, Nedjar H, Bizzi A, et al. Hospitalization for gastrointestinal adverse events attributable to the use of low-dose aspirin among patients 50 years or older also using non-steroidal anti-inflammatory drugs: a retrospective cohort study. Aliment Pharmacol Ther 2007; 26(10): 1387–98
PubMed
CAS
Article
Google Scholar
van der Linden MW, van der Bij S, Welsing P, et al. The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis 2009 May; 68(5): 668–73
PubMed
Article
Google Scholar
MacDonald TM, Morant SV, Goldstein JL, et al. Channelling bias and the incidence of gastrointestinal haemorrhage in users of meloxicam, coxibs, and older, non-specific non-steroidal anti-inflammatory drugs. Gut 2003; 52(9): 1265–70
PubMed Central
PubMed
CAS
Article
Google Scholar
Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat 2000; 5(2): 137–42
PubMed
CAS
Google Scholar
García Rodríguez LA, Hernández-Díaz S. Risk of uncomplicated peptic ulcer among users of aspirin and non-aspirin nonsteroidal antiinflammatory drugs. Am J Epidemiol 2004 Jan 1; 159(1): 23–31
PubMed
Article
Google Scholar
Traversa G, Walker AM, Ippolito FM, et al. Gastroduodenal toxicity of different nonsteroidal antiinflammatory drugs. Epidemiology 1995; 6(1): 49–54
PubMed
CAS
Article
Google Scholar
Battistella M, Mamdami MM, Juurlink DN, et al. Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors. Arch Intern Med 2005; 165(2): 189–92
PubMed
CAS
Article
Google Scholar
Kaplan RC, Heckbert SR, Psaty BM. Risk factors for hospitalized upper or lower gastrointestinal tract bleeding in treated hypertensives. Prev Med 2002; 34(4): 455–62
PubMed
Article
Google Scholar
Kaufman DW, Kelly JP, Wiholm BE, et al. The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. Am J Gastroenterol 1999 Nov; 94(11): 3189–96
PubMed
CAS
Article
Google Scholar
García Rodríguez LA, Walker AM, Pérez Gutthann S. Nonsteroidal antiinflammatory drugs and gastrointestinal hospitalizations in Saskatchewan: a cohort study. Epidemiology 1992; 1992(3): 337–42
Article
Google Scholar
Jick SS. The risk of gastrointestinal bleed, myocardial infarction, and newly diagnosed hypertension in users of meloxicam, diclofenac, naproxen, and piroxicam. Pharmacotherapy 2000; 20(7): 741–4
PubMed
CAS
Article
Google Scholar
Morant SV, Pettitt D, MacDonald TM, et al. Application of a propensity score to adjust for channelling bias with NSAIDs. Pharmacoepidemiol Drug Saf 2004; 13(6): 345–53
PubMed
CAS
Article
Google Scholar
Rahme E, Nedjar H. Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study. Rheumatology (Oxford) 2007; 46(3): 435–8
CAS
Article
Google Scholar
Beard K, Walker AM, Perera DR, et al. Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly. Arch Intern Med 1987; 147(9): 1621–3
PubMed
CAS
Article
Google Scholar
Fries JF, Bruce B. Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. J Rheumatol 2003; 30(10): 2226–33
PubMed
CAS
Google Scholar
Jick H, Feld AD, Perera DR. Certain nonsteroidal antiinflammatory drugs and hospitalization for upper gastrointestinal bleeding. Pharmacotherapy 1985; 5(5): 280–4
PubMed
CAS
Google Scholar
Lanza LL, Walker AM, Bortnichak EA, et al. Peptic ulcer and gastrointestinal hemorrhage associated with non-steroidal anti-inflammatory drug use in patients younger than 65 years: a large health maintenance organization cohort study. Arch Intern Med 1995; 155(13): 1371–7
PubMed
CAS
Article
Google Scholar
Mellemkjaer L, Blot WJ, Sorensen HT, et al. Upper gastrointestinal bleeding among users of NSAIDs: a population-based cohort study in Denmark. Br J Clin Pharmacol 2002; 53(2): 173–81
PubMed Central
PubMed
CAS
Article
Google Scholar
Schneeweiss S, Solomon DH, Wang PS, et al. Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis. Arthritis Rheum 2006; 54(11): 3390–8
PubMed
CAS
Article
Google Scholar
van Soest EM, Sturkenboom MC, Dieleman JP, et al. Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage. Aliment Pharmacol Ther 2007 Jul 15; 26(2): 265–75
PubMed
Article
Google Scholar
McIntosh JH, Byth K, Piper DW. Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms. Gut 1985; 26(8): 789–98
PubMed Central
PubMed
CAS
Article
Google Scholar
McIntosh JH, Fung CS, Berry G, et al. Smoking, non-steroidal anti-inflammatory drugs, and acetaminophen in gastric ulcer: a study of associations and of the effects of previous diagnosis on exposure patterns. Am J Epidemiol 1988; 128(4): 761–70
PubMed
CAS
Google Scholar
Pilotto A, Franceschi M, Leandro G, et al. The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res 2003 Dec; 15(6): 494–9
PubMed
CAS
Article
Google Scholar
Castellsague J, Holick CN, Hoffman CC, et al. Risk of upper gastrointestinal complications associated with cyclooxygenase-2 selective and nonselective nonsteroidal antiinflammatory drugs. Pharmacotherapy 2009 Dec; 29(12): 1397–407
PubMed
CAS
Article
Google Scholar
Chang CH, Chen HC, Lin JW, et al. Risk of hospitalization for upper gastrointestinal adverse events associated with nonsteroidal anti-inflammatory drugs: a nationwide case-crossover study in Taiwan. Pharmacoepidemiol Drug Saf 2011 Jul; 20(7): 763–71
PubMed
CAS
Article
Google Scholar
Rothman KJ, Greenland S, Lash TL. Design strategies to improve study accuracy. In: Rothman KJ, Greenland S, Lash TL, editors. Modern epidemiology. 3rd ed. Philadelphia (PA): Lippincott Williams & Wilkins, 2008: 168–82
Google Scholar
Ray WA. Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol 2003 Nov 1; 158(9): 915–20
PubMed
Article
Google Scholar
Suissa S, Garbe E. Primer: administrative health databases in observational studies of drug effects — advantages and disadvantages. Nat Clin Pract Rheumatol 2007 Dec; 3(12): 725–32
PubMed
CAS
Article
Google Scholar
García Rodríguez LA, Ruigómez A. Case validation in research using large databases. Br J Gen Pract 2010 Mar; 60(572): 160–1
PubMed Central
PubMed
Article
Google Scholar
Raiford DS, Pérez Gutthann S, García Rodríguez LA. Positive predictive value of ICD-9 codes in the identification of cases of complicated peptic ulcer disease in the Saskatchewan hospital automated database. Epidemiology 1996 Jan; 7(1): 101–4
PubMed
CAS
Article
Google Scholar
Cattaruzzi C, Troncon MG, Agostinis L, et al. Positive predictive value of ICD-9th codes for upper gastrointestinal bleeding and perforation in the Sistema Informativo Sanitario Regionale database. J Clin Epidemiol 1999; 52(6): 499–502
PubMed
CAS
Article
Google Scholar
Lin KJ, García Rodríguez LA, Hernández-Díaz S. Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates? Pharmacoepidemiol Drug Saf 2011 Jul; 20(7): 718–28
PubMed
Article
Google Scholar
McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med 2011 Sep; 8(9): e1001098
PubMed Central
PubMed
CAS
Article
Google Scholar
Varas-Lorenzo C, Riera-Guardia N, Calingaert B, et al. The SOS Project. Risk of acute myocardial infarction and use of NSAIDs: a meta-analysis of epidemiological studies. Pharmacoepidemiol Drug Saf 2010; 19(S1): S142–S3
Google Scholar
Varas-Lorenzo C, Riera-Guardia N, Calingaert B, et al. Stroke risk and NSAIDs: a systematic review of observational studies. Pharmacoepidemiol Drug Saf 2011 Dec; 20(12): 1225–36
PubMed
Article
Google Scholar