Summary
The effects of E3810, a potent proton pump inhibitor, on gastric secretion and gastric or duodenal ulcers or erosions were studied in rats. Intraduodenal administration of E3810 dose dependently inhibited gastric secretion (volume and acid outputs) in pylorus-ligated rats. The effective dose required to inhibit volume output by 50% (ED50) was 12 mg/kg and that for acid output was 3.4 mg/kg. Acutely induced gastric ulcers or erosions, such as cold-restraint stress erosions, Shay ulcers and mercaptamine (cysteamine)-induced duodenal ulcers, were significantly inhibited by oral, intraduodenal or subcutaneous administration of E3810 at 1 to 100 mg/kg. The protective effects of E3810 in these acute models were compared with those of omeprazole at the same doses. At low doses, 10 mg/kg (intraduodenally) in Shay ulcers and 3 mg/kg (subcutaneously) in mercaptamine-induced ulcers, E3810 was significantly more effective than omeprazole. But at high doses, there was no significant difference between the 2 drugs in efficacy. In the cold stress erosion model, the drugs were equally effective.
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Fujisaki, H., Shibata, H., Oketani, K. et al. Effects of the Proton Pump Inhibitor, E3810, on Gastric Secretion and Gastric and Duodenal Ulcers or Erosions in Rats. Drug Invest. 3, 328–332 (1991). https://doi.org/10.1007/BF03259747
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DOI: https://doi.org/10.1007/BF03259747