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Animal Pharmacology of Nebivolol

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Summary

Nebivolol is a mixture of equal amounts of 2 enantiomers: SR3-nebivolol (d-nebivolol) and RS3-nebivolol (l-nebivolol). SR3-nebivolol is a potent and selective β1-adrenergic antagonist both in vitro and in vivo. Nebivolol acutely lowers blood pressure in spontaneously hypertensive rats and induces a slight decrease in total peripheral vascular resistance and a slight increase in cardiac output in anaesthetised dogs. These haemodynamic effects cannot be explained by β1-adrenergic antagonism and are largely attributable to RS3-nebivolol.

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Authors and Affiliations

  1. Department of Cardiovascular Pharmacology, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium

    W. J. Janssens, R. Xhonneux & P. A. J. Janssen

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  1. W. J. Janssens
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  2. R. Xhonneux
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  3. P. A. J. Janssen
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Janssens, W.J., Xhonneux, R. & Janssen, P.A.J. Animal Pharmacology of Nebivolol. Drug Invest 3 (Suppl 1), 13–24 (1991). https://doi.org/10.1007/BF03258258

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