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Serum Tests for Colorectal Cancer Screening

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Abstract

Colorectal cancer (CRC) persists as one of the most significant causes of cancer death worldwide. Recent progress in reducing cancer mortality can largely be attributed to the implementation of screening programs. However, screening programs have not realized their full potential for the reduction of CRC mortality, because of poor adherence rates among patients. Serum biomarker screening tests offer the potential for improved patient adherence to CRC screening programs.

In this review, we assess the literature regarding serum biomarkers for use as CRC screening tests for colorectal cancer and adenomas. A systematic review was performed of Medline-indexed articles pertaining to serum biomarkers for CRC screening published within the past 4 years. In addition, we searched non-Medline sources for information pertaining to screening guidelines and practice patterns for CRC. We identified 51 articles from Medline pertaining to serum biomarkers as screening tests for CRC. Non-Medline sources yielded an additional 12 articles, for a total of 63 publications reviewed. We conclude that serum tests that involve simple blood draws during routine check-ups hold significant promise for improving patient acceptance and adherence to CRC screening.

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Acknowledgments

The funding for this review was provided by Roche Diagnostics, Ltd, who provided feedback for the design and content of the manuscript. Douglas Rex was a paid consultant for his role in the development of this manuscript. Dr. Rex has also received honoraria from Roche for other projects and is a consultant for Epigenomics AG. Frank Junker, Sabine Vogel-Ziebolz, and James Creeden are employees of Roche Diagnostics. Leora Schiff and Talia Foster (United BioSource Corporation, Inc., Lexington, MA, USA) provided editorial and writing support for this manuscript, funded by Roche Diagnostics, Ltd.

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  1. Roche Diagnostics, Ltd, Forrenstrasse, CH-6343, Rotkreuz, Switzerland

    James Creeden & Frank Junker

  2. Roche Diagnostics, GmbH, Penzberg, Germany

    Sabine Vogel-Ziebolz

  3. Indiana University Hospital, Indianapolis, IN, USA

    Douglas Rex

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Creeden, J., Junker, F., Vogel-Ziebolz, S. et al. Serum Tests for Colorectal Cancer Screening. Mol Diag Ther 15, 129–141 (2011). https://doi.org/10.1007/BF03256403

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