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Tetrabutylammonium bromide promoted efficient and chemoselective trimethylsilylation of primary and secondary alcohols under mild reaction conditions

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Abstract

A mild and efficient method for trimethylsilylation of alcohols with hexamethyldisilazane (HMDS) catalyzed by tetrabutylammonium bromide is reported. The method is highly chemoselective for the o-protection of primary and secondary alcohols in the presence of amines, thiols and tertiary alcohols.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, The University of Guilan, Rasht, Germany

    F. Shirini & M. Abedini

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  1. F. Shirini
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  2. M. Abedini
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Correspondence to F. Shirini.

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This article is dedicated to Professor Habib Firouzabadi on the occasion of his 65th birthday, for his great contribution to the development of organic chemistry in Iran

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Shirini, F., Abedini, M. Tetrabutylammonium bromide promoted efficient and chemoselective trimethylsilylation of primary and secondary alcohols under mild reaction conditions. JICS 5 (Suppl 1), S87–S90 (2008). https://doi.org/10.1007/BF03246494

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  • DOI: https://doi.org/10.1007/BF03246494

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