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Zr(HSO4)4 catalyzed one-pot strecker synthesis of α-amino nitriles from aldehydes and ketones under solvent-free conditions

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Abstract

A mild and efficient method has been developed for the preparation of α-amino nitriles from the condensation of aldehydes and ketones with aniline and TMSCN in the presence of a catalytic amount of Zr(HSO4)4 under solvent-free conditions at room temperature.

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Authors and Affiliations

  1. Dept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI, 53706-1532, USA

    A. R. Hajipour

  2. Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, 84156, IR Iran

    A. R. Hajipour, Y. Ghayeb & N. Sheikhan

Authors
  1. A. R. Hajipour
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  2. Y. Ghayeb
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  3. N. Sheikhan
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Correspondence to A. R. Hajipour.

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Hajipour, A.R., Ghayeb, Y. & Sheikhan, N. Zr(HSO4)4 catalyzed one-pot strecker synthesis of α-amino nitriles from aldehydes and ketones under solvent-free conditions. JICS 7, 447–454 (2010). https://doi.org/10.1007/BF03246031

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  • DOI: https://doi.org/10.1007/BF03246031

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