Abstract
A novel synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by one-pot cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using nafion-H as the catalyst under ultrasound irradiation and solvent-free conditions was developed. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, excellent yields, easy work up and short reaction time.
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Wang, Q., Pei, W. Synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by nafion-H under ultrasound irradiation and solvent-free conditions. JICS 7, 318–321 (2010). https://doi.org/10.1007/BF03246016
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DOI: https://doi.org/10.1007/BF03246016