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6-arm PLLA-PEG block copolymers for micelle formation and controlled drug release

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Conclusions

A series of novel 6-arm PLLA-PEG copolymers was synthesized for drug delivery system. This block copolymer was prepared by conjugating PEG to 6-arm PLLA. The 6-arm PLLA-PEGs formed micelle at aqueous solution, showing different sizes and loading efficiency of IMC by changing PLLA chain length. Overall release profiles of IMC from 6-arm PLLA-PEG micelles showed no initial burst and prolonged release time. Particularly, 6-arm PLLA-PEG micelles with longer PLLA chain showed more sustained release behaviors. The release rate of IMC can be modulated with the chain length of PLLA.

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Authors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, 443-749, Suwon, Korea

    Yoon Ki Joung, Jung Sik Lee & Ki Dong Park

  2. Department of Pharmacy, College of Pharmacy, Ewha Womans University, 120-750, Seoul, Korea

    Seung-Jin Lee

Authors
  1. Yoon Ki Joung
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  2. Jung Sik Lee
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  3. Ki Dong Park
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  4. Seung-Jin Lee
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Correspondence to Ki Dong Park.

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Joung, Y.K., Lee, J.S., Park, K.D. et al. 6-arm PLLA-PEG block copolymers for micelle formation and controlled drug release. Macromol. Res. 16, 66–69 (2008). https://doi.org/10.1007/BF03218963

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  • DOI: https://doi.org/10.1007/BF03218963

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