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Sulfonated poly(ethylene glycol) containing methacrylate copolymer surfaces; preparation, characterization andin vitro biocompatibility

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Abstract

Poly(ethylene glycol) (PEG1K) and sulfonated PEG (PEG1K-SO3) methacrylate (MA) copolymers have been prepared and characterized. The structures of the synthesized copolymers were confirmed by1H and13C NMR spectroscopy and elemental analysis. The bulk characteristics of the copolymers were evaluated by viscosity and thermal analysis. The surface properties of the copolymers were investigated using dynamic contact angle measurements and electron spectroscopy for chemical analysis. The hydrophilicity of the surfaces modified with PEG1KMA or PEG1K-SO3MA increased, possibly as a result of the orientation of the hydrophilic PEG1KMA/ PEG1K-SO3MA chains into the water phase. Platelets adhered less to the surfaces of the copolymers than they did to a polyurethane control. In addition, adhesion of platelets to the copolymer surfaces decreased upon increasing the chain density of PEG1KMA and sulfonated PEG1KMA in the copolymers. Both bacterial adhesion and protein adsorption were significantly reduced on the copolymer surfaces and their levels differ depending on the kind of surface or media.

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Authors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, 442-749, Suwon, Korea

    Ki Dong Park & Hyung Dal Park

  2. Research Center, Korea Institute of Science and Technology, Cheongryang, P.O. Box 131, 130-650, Seoul, Korea

    Hee Jung Lee & Yong Ha Kim

  3. School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, 923-1292, Ishikawa, Japan

    Tooru Ooya & Nobuhiko Yui

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  1. Ki Dong Park
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  2. Hyung Dal Park
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  6. Nobuhiko Yui
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Park, K.D., Park, H.D., Lee, H.J. et al. Sulfonated poly(ethylene glycol) containing methacrylate copolymer surfaces; preparation, characterization andin vitro biocompatibility. Macromol. Res. 12, 342–351 (2004). https://doi.org/10.1007/BF03218410

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  • DOI: https://doi.org/10.1007/BF03218410

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