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Preparation and characterization of water-dispersible silver nanoparticles stabilized by PEO-conjugated pro-drugs

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Abstract

ω-Anhydride-functionalized poly(ethylene oxide) (PEO) obtained from chain-end functionalization and anionic ring-opening polymerization of ethylene oxide usingn-butyllithium with potassiumt-butoxide in the presence of dimethylsulfoxide (DMSO) was found to be an efficient material for the preparation of water-soluble, polymeric pro-drugs. The reaction of ω-anhydride-functionalized PEO with sulfonamide or with vancomycin provided an efficient method to produce corresponding, water-soluble, PEO-conjugated sulfonamide or PEO-conjugated, vancomycin pro-drugs. These were used successfully to prepare water-dispersible, silver nanoparticles. In this study, the particle sizes were in the range of 5∼40 nm. The resulting products were characterized by1H NMR spectroscopy, transmission electron microscopy, electron and X-ray diffraction, size exclusion chromatography, and UV/Visible spectroscopy.

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References

  1. C. B. Murray, S. Sun, H. Doyle, and T. Betley,Mater. Res. Soc. Bull.,26, 985 (2001).

    CAS  Google Scholar 

  2. B. Wiley, Y. Sun, J. Chen, H. Cang, Z.-Y. Li, X. Li, and Y. Xia,Mater. Res. Soc. Bull.,30, 356 (2005).

    Article  CAS  Google Scholar 

  3. Y. Sun and Y. Xia,Science,298, 2176 (2002).

    Article  CAS  Google Scholar 

  4. J. Wang, G. Liu, and A. Merkovi,J. Am. Chem. Soc.,125, 3214 (2003).

    Article  CAS  Google Scholar 

  5. R. Bau, J. Zhang, E. J. Beckman, M. Virji, W. A. Pasculle, and A. Wells,Biomaterials,27, 4304 (2006).

    Article  Google Scholar 

  6. A. Panacek, L. Kvitek, R. Prucek, M. Kolar, R. Vecerova, N. Pizurova, V. K. Sharma, T. Nevecna, and R. Zboril,J. Phys. Chem. B,110, 16248 (2006).

    Article  CAS  Google Scholar 

  7. R. W.-Y. Sun, R. Chen, N. P.-Y. Chung, C.-M. Ho, C.-L. S. Lin, and C.-M. Che,Chem. Commun., 5059 (2005).

  8. L. Lu, A. Kobayashi, K. Tawa, and Y. Ozaki,Chem. Mater.,18, 4894 (2006).

    Article  CAS  Google Scholar 

  9. X. Zou and S. Dong,J. Phys. Chem. B,110, 21545 (2006).

    Article  CAS  Google Scholar 

  10. E. V. Schevchenko, D. V. Talapin, H. Schnablegger, A. Kornowski, O. Festin, P. Svedlindh, M. Haase, and H. Weller,J. Am. Chem. Soc.,125, 9090 (2003).

    Article  Google Scholar 

  11. R. Narayanan and M. A. El-Sayed,J. Am. Chem. Soc.,125, 8340 (2003).

    Article  CAS  Google Scholar 

  12. B. J. Wiley, S. H. Im, Z.-Y. Li, J. McLellan, A. Siekkinen, and Y. Xia,J. Phys. Chem. B,110, 15666 (2006).

    Article  CAS  Google Scholar 

  13. B. J. Wiley, Y. Sun, B. Mayers, and Y. Xia,Chem. Eur. J.,11, 454 (2005).

    Article  CAS  Google Scholar 

  14. A. Gupta and S. Silver,Nature Biotechnol.,16, 888 (1998).

    Article  CAS  Google Scholar 

  15. J. R. Morones, J. L. Elechiguerra, A. Camacho, K. Holt, J. B. Kouri, J. T. Ramirez, and M. J. Yacaman,Nanotechnology,16, 2346 (2005).

    Article  CAS  Google Scholar 

  16. M. Moskovits and J. S. Suh,J. Am. Chem. Soc.,107, 6826 (1985).

    Article  CAS  Google Scholar 

  17. R. P. Cheung and J. T. DiPiro,Pharmacotherapy,6, 153 (1986).

    CAS  Google Scholar 

  18. H. Ringsdorf,J. Polym. Sci. Symp.,51, 135 (1975).

    Article  CAS  Google Scholar 

  19. C. T. Supuran, A. Casini, and A. Scozzafava,Med. Res. Rev.,23, 535 (2003).

    Article  CAS  Google Scholar 

  20. M. Morton and L. J. Fetters,Rubber Chem. Technol.,48, 359 (1975).

    Article  CAS  Google Scholar 

  21. J. Kim, S. Choi, K. M. Kim, C. H. Lee, H. S. Park, S. S. Hwang, S. M. Hong, S. Kwak, and H.-O. Yoo,Macromol. Symp.,245/246, 565 (2006).

    Article  CAS  Google Scholar 

  22. H. Gilman and F. K. Cartledge,J. Organomet. Chem.,2, 447 (1964).

    Article  CAS  Google Scholar 

  23. J. Kim, S. Choi, K. M. Kim, D. H. Go, H. J. Jeon, J. Lee, H. S. Park, C. H. Lee, and H. M. Park,Macromol. Res.,15, 31 (2007).

    Google Scholar 

  24. J. M. Harris and R. B. Chess,Nature Rev. Drug Dis.,2, 214 (2003).

    Article  CAS  Google Scholar 

  25. B. Wiley, Y. Sun, B. Mayers, and Y. Xia,Chem. Eur. J.,11, 454 (2005).

    Article  CAS  Google Scholar 

  26. D. E. Sands,Introduction to Crystallography, Dover, New York, 1993, p 51.

    Google Scholar 

  27. M. S. Lisowski, Q. Liu, J. Cho, J. Runt, F. Yeh, and B. S. Hsiao,Macromolecules,33, 4842 (2000).

    Article  CAS  Google Scholar 

  28. S. Panigrahi, S. Praharaj, S. Basu, S. K. Ghosh, S. Jana, S. Pande, T. Vo-Dinh, H. Jiang, and T. Pal,J. Phys. Chem. B,110, 13436 (2006). (b) S. He, J. Yao, S. Xie, H. Gao, and S. Pang,J. Phys. D: Appl. Phys.,34, 3425 (2001). (c) Y. Gao, P. Jiang, D. F. Liu, H. J. Yuan, X. Q. Yan, Z. P. Zhou, J. X. Wang, L. Song, L. F. Liu, W. Y. Zhou, G. Wang, C. Y. Wang, S. S. Xie, J. M. Zhang, and D. Y. Shen,J. Phys. Chem. B,108, 12877 (2004). (d) H. Xia, Y. Zhang, S. Sun, and Y. Fang,Colloid Polym. Sci.,285, 1655 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Kyunghee University, 130-701, Seoul, Korea

    Tae Hwan Kim, Keunsuk Kim, Geon Hee Park, Jin Hee Choi, Sangmi Lee, Ho-Jung Kang, Jae Yeol Lee & Jungahn Kim

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  1. Tae Hwan Kim
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  2. Keunsuk Kim
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  3. Geon Hee Park
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  4. Jin Hee Choi
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  7. Jae Yeol Lee
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Correspondence to Jungahn Kim.

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Kim, T.H., Kim, K., Park, G.H. et al. Preparation and characterization of water-dispersible silver nanoparticles stabilized by PEO-conjugated pro-drugs. Macromol. Res. 17, 770–775 (2009). https://doi.org/10.1007/BF03218613

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  • DOI: https://doi.org/10.1007/BF03218613

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