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Synthesis of new pH-sensitive poly(ethylene oxide-b-maleic acid) from modification of poly(ethylene oxide-b-N-phenylmaleimide)

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Abstract

A new and useful poly(ethylene oxide)-based pH-sensitive block copolymer is introduced. Poly(ethylene oxide-b-N-phenylmaleimide) was first synthesized by anionic polymerization of N-phenylmaleimide (N-PMI) using mixed alkali metal polymeric alkoxide by sequential monomer addition method in the mixture of benzene/THF/ DMSO (10/5/3, v/v/v) at room temperature. Reductive deimidation of the resulting block copolymer was performed using hydrazine monohydrate leading to the formation of the corresponding pH-sensitive poly(ethylene oxide-bmaleic acid).

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References

  1. A. Gessner, B.-R. Paulke, R. H. Muller, and T. M. Goppert,Pharmazie,61, 293 (2006).

    CAS  Google Scholar 

  2. S. Takae, Y. Akiyama, H. Ossuka, T. Nakamura, Y. Nansaki, and K. Kataoka,Biomacromolecules,6, 818 (2005); (b) S. J. Hwang, M. S. Kim, J. K. Han, D. S. Lee, B. S. Kim, E. K. Choi, H. J. Park, and J. S. Kim,Macromol. Res.,15, 437 (2007).

    Article  CAS  Google Scholar 

  3. J. Kim, S. Choi, K. M. Kim, D. H. Go, H. J. Jeon, J. Y. Lee, H. S. Park, C. H. Lee, and H. M. Park,Macromol. Res.,15, 337 (2007).

    Article  CAS  Google Scholar 

  4. S. Thamizharasi and B. S. R. Reddy,J. Appl. Polym. Sci.,80, 1870 (2001).

    Article  CAS  Google Scholar 

  5. X. Jiang, P. Xia, W. Liu, and D. Yan,J. Polym. Sci. Part A: Polym. Chem.,38, 1203 (2000).

    Article  CAS  Google Scholar 

  6. B. Zhao, Y. Wang, C. Lu, Q. Shen, and M. Deng,J. Polym. Sci. Part A: Polym. Chem.,43, 3966 (2005).

    Article  CAS  Google Scholar 

  7. T. Hagiwara, T. Shimizu, T. Someno, T. Yamagishi, H. Hamana, and T. Narita,Macromolecules,21, 3324 (1988).

    Article  CAS  Google Scholar 

  8. T. Oishi, K. Onimura, K. Tanaka, W. Horimoto, and H. Tsutsumi,J. Polym. Sci. Part A: Polym. Chem.,37, 473 (1999).

    Article  Google Scholar 

  9. Y. Isobe, K. Onimura, H. Tsutsumi, and T. Oishi,J. Polym. Sci. Part A: Polym. Chem.,39, 3556 (2001).

    Article  CAS  Google Scholar 

  10. R. C. P. Cubbon,Polymer,6, 419 (1965).

    Article  CAS  Google Scholar 

  11. N. Hadjichristidis, S. Pispas, and G. Floudas,Block Copolymers: Synthetic Strategies, Physical Properties, and Applications, Wiley-Interscience, New Jersey, 2003.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, Kyunghee University, 130-701, Seoul, Korea

    Da Hyeon Go, Hee Jeong Jeon, Tae Hwan Kim, Geunseok Kim, Jin Hee Choi, Jae Yeol Lee & Jungahn Kim

  2. Department of Chemical Engineering, Hanyang University, 133-791, Seoul, Korea

    Hyun-Oh Yoo

  3. Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 84108, Salt Lake City, UT, USA

    You Han Bae

Authors
  1. Da Hyeon Go
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  2. Hee Jeong Jeon
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  3. Tae Hwan Kim
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  4. Geunseok Kim
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  5. Jin Hee Choi
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  6. Jae Yeol Lee
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  7. Jungahn Kim
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  8. Hyun-Oh Yoo
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  9. You Han Bae
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Correspondence to Jungahn Kim.

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Go, D.H., Jeon, H.J., Kim, T.H. et al. Synthesis of new pH-sensitive poly(ethylene oxide-b-maleic acid) from modification of poly(ethylene oxide-b-N-phenylmaleimide). Macromol. Res. 16, 659–662 (2008). https://doi.org/10.1007/BF03218576

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  • DOI: https://doi.org/10.1007/BF03218576

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