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Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits

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Summary

Danggui is a popular traditional Chinese medicinal (TCM) herb which is easily obtained by the public. The effects of Danggui on the pharmacokinetics and pharmacodynamics of warfarin were studied in rabbits.

Single subcutaneous doses (2 mg/kg) of warfarin were administered to 6 rabbits with or without 3 days treatment with oral Danggui extracts (2 g/kg twice daily). Plasma warfarin concentrations were measured by high performance liquid chromatography (HPLC) for 72 h after each of the two warfarin doses. The prothrombin time (PT) was measured daily for 3 days both during the Danggui treatment period and after warfarin doses. Danggui treatment did not affect PT on its own, but significantly lowered PT values 3 days after co-treatment with single dose warfarin. No significant variations in the single dose pharmacokinetic parameters of warfarin were observed after Danggui treatment.

A separate group of 6 rabbits were given daily subcutaneous doses of warfarin (0.6 mg/kg) to achieve steady state level, followed by 3 day treatment with oral Danggui extract (2 g/kg twice daily). The slight increase in PT was not significant and two rabbits died after day 7 of the treatment period. However, there was no significant difference in steady state concentrations of warfarin after the Danggui treatment. Results indicate that precautionary advice should be given to patients who self-medicate with Danggui or other TCM products while on chronic treatment with warfarin.

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References

  1. Chou Y.P. (1979): The effects ofAngelica sinensis on haemodynamics and myocardial oxygen consumption in dogs. Acta Pharma. Sinica, 14, 156.

    CAS  Google Scholar 

  2. Tang W., Eisenbrand G. (1992):Angelica species, In: Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine. Germany, Springer-Verlag, pp. 113–125.

    Google Scholar 

  3. Chang H.M., But P.P.H. (1986): Danggui. In: Pharmacology and applications of Chinese Material Medica, Vol 1. World Scientific Publishing Co. Ltd, pp 489–505.

  4. Wei Z.M. (1985): A study on the electro-physiology in antiarrhythmia effect ofAngelica sinensis. J. Beijing College Tradit. Chin. Med., 8, 40–51.

    Google Scholar 

  5. Tu J.J. (1982): Haemorheological observation after acute ischaemic apoplexy treated withAngelica sinensis. J. Tradit. Chin. Med., 23, 762–770.

    Google Scholar 

  6. Tao J.Y. (1984): Studies on the antiasthmatic action of ligustilide of Danggui,Angelica sinensis (Oliv)Diels. Acta. Pharm. Sinica, 19, 561–567.

    CAS  Google Scholar 

  7. Tanaka S. (1977): Studies on anti-nociceptive activities of aqueous extracts from different varieties of Danggui. J. Pharm. Soc. Jpn, 91, 14–24.

    Google Scholar 

  8. Wang Z. (1988): Sodium ferulate is an inhibitor of thromboxane A2 synthetase. Acta. Pharm. Sinica, 9, 430–438.

    CAS  Google Scholar 

  9. Xu L.N. (1990): Effect of sodium ferulate on arachidonic acid metabolism. Acta Pharm. Sinica, 25, 412–423.

    CAS  Google Scholar 

  10. Ma L.F. (1988): The effect ofAngelica sinensis on mouse marrow haemopoiesis. Chin. J. Haematol., 9, 148.

    CAS  Google Scholar 

  11. Wu W.T. (1989): Biological activities ofAngelica sinensis and ferulic acid on the murine spleen lymphocytes. J. China Pharmaceut. Univ., 20, 219–225

    CAS  Google Scholar 

  12. Huang K.C. (1993): Herbs affecting the uterus. In: The Pharmacology of Chinese Herbs. CRC Press, pp. 247–248.

  13. Lo A.C.T., Chan K., Yeung J.H.K., Woo K.S. (1992): The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. Eur. J. Drug Metab. Pharmacokinet., 17, 257–262.

    CAS  PubMed  Google Scholar 

  14. Chan K., Dehghan A. (1978): The isolation and determination of neostigmine, pyridostigmine and their metabolites in human biological fluids. J. Pharmacol. Meth., 1, 311–320.

    Article  CAS  Google Scholar 

  15. Chan K., Woo K.S. (1988): Determination of warfarin in human plasma by high performance liquid chromatography, Meth. Find. Exp. Clin. Pharmacol., 10, 699–703.

    CAS  Google Scholar 

  16. Breckenridge A.M. (1977): Individual differences on the response to oral anticoagulants. Drugs, 14, 367–375.

    Article  CAS  PubMed  Google Scholar 

  17. Park B.K. (1988): Warfarin, metabolism and mode of action. Biochem. Pharmacol., 37, 19–27.

    Article  CAS  PubMed  Google Scholar 

  18. Bjornsson T.D., Meffin P.J., Swezey S. (1979): Clofibrate displaces warfarin from plasma proteins in man: an example of a pure displacement interaction. J. Pharmacol. Exp. Therap., 210, 316–321.

    CAS  Google Scholar 

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Author notes

  1. A. C. T. Lo

    Present address: Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia

Authors and Affiliations

  1. Department of Pharmacology, The Chinese University of Hong Kong, Shatin, Hong Kong

    A. C. T. Lo, K. Chan (Professor) & J. H. K. Yeung

  2. Department of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

    K. S. Woo

Authors
  1. A. C. T. Lo
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  2. K. Chan
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  3. J. H. K. Yeung
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  4. K. S. Woo
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Lo, A.C.T., Chan, K., Yeung, J.H.K. et al. Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits. Eur. J. Drug Metab. Pharmacokinet. 20, 55–60 (1995). https://doi.org/10.1007/BF03192289

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  • DOI: https://doi.org/10.1007/BF03192289

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