Summary
In this study, the kinetics of pyrimethamine elimination via the urine was investigated. The experiments were carried out on six healthy male volunteers aged 23–32 years. The drug was administered orally (p.o.) in a single dose at three different concentrations i.e.: 50, 75 and 100 mg. The concentration of the drug in the urine was determined via the modified method of Bonini et al. and Garber et al. It was found that 13.4±1.3% of the dose eliminated via the urine was in unchanged form. The process of pyrimethamine elimination may be described according to an open kinetic two-compartmental model: the formula showing the course of pyrimethamine elimination over time has been given. Several examples of the quantitative exposure test have been proposed, which allow the calculation of the drug dose absorbed and thus the degree of toxicity to be determined. This test can also be useful in a controlled clinical setting.
Similar content being viewed by others
References
Bardodej Z. (1964): Metabolismus styrene. Cs. Hyg., 9, 223–239.
Piotrowski J. (1967): Ilosciowa ocena wchlaniania toluenu u ludzi. Med. Pracy, 18, 213–223.
Dutkiewicz T. (1971): Wydalanie benzenu przez pluca u osob narazonych na wchlanianie benzenu. Bromat. Chem. Toksykol., 4, 443–447.
Ogata M., Takatsuka Y., Tomokuni K. (1971): Excretion of hippuric acid and m- or p-methylhyppuric acid in the urine of persons exposed to vapors of toluene and m- or p-xylene in an exposure chamber and in workshops. Br. J. Industr. Med., 28, 382–385.
Senczuk W., Litewka B. (1976): Absorption of cumene through the respiratory tract and excretion of dimethylphenylcarbinol in urine. Br. J. Industr. Med., 33: 100–105.
Senczuk W., Jodynis-Liebert J. (1979): Studies on kinetics of anturan excretion in man. Int. J. Clin. Pharmacol. Biopharm., 17, 303–306.
Bonini M., Argilas S. (1981): Contribution au dosage de quatre antipaludéens (chloroquine, quinine, pyriméthamine, sulfadoxine) en mélange dans les milieu biologiques. Toxicol. Eur. Res., III (3), 119–123.
Garber J.B., Fink D.W., Szalkowski C.R. (1973): Colorimetric determination of pyrimethamine in feeds. J. Assoc. Anal. Chem., 56, 1161–1163.
Midskov C. (1984): Rapid gas chromatographic determination of pyrimethamine in human plasma and urine. J. Chromatogr., 306, 388–393.
Bardodej Z. (1964): Metabolismus styrene. Cs. Hyg., 9, 223–239.
Piotrowski J. (1967): Ilosciowa ocena wchlaniania toluenu u ludzi. Med. Pracy, 18, 213–223.
Dutkiewicz T. (1971): Wydalanie benzenu przez pluca u osob narazonych na wchlanianie benzenu. Bromat. Chem. Toksykol., 4, 443–447.
Ogata M., Takatsuka Y., Tomokuni K. (1971): Excretion of hippuric acid and m- or p-methylhyppuric acid in the urine of persons exposed to vapors of toluene and m- or p-xylene in an exposure chamber and in workshops. Br. J. Industr. Med., 28, 382–385.
Senczuk W., Litewka B. (1976): Absorption of cumene through the respiratory tract and excretion of dimethylphenylcarbinol in urine. Br. J. Industr. Med., 33, 100–105.
Senczuk W., Jodynis-Liebert J. (1979): Studies on kinetics of anturan excretion in man. Int. J. Clin. Pharmacol. Biopharm., 17, 303–306.
Bonini M., Argilas S. (1981): Contribution au dosage de quatre antipaludéens (chloroquine, quinine, pyriméthamine, sulfadoxine) en mélange dans les milieu biologiques. Toxicol. Eur. Res., III (3), 119–123.
Garber J.B., Fink D.W., Szalkowski C.R. (1973): Colorimetric determination of pyrimethamine in feeds. J. Assoc. Anal. Chem., 56, 1161–1163.
Midskov C. (1984): Rapid gas chromatographic determination of pyrimethamine in human plasma and urine. J. Chromatogr., 306: 388–393.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mouankie, J.B., Senczuk, W. & Florek, E. Urinary elimination kinetics of pyrimethamine. Eur. J. Drug Metabol. Pharmacokinet. 34, 169–172 (2009). https://doi.org/10.1007/BF03191169
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03191169