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Paeonol pharmacokinetics in the rat following i.m. administration

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Summary

The pharmacokinetic behavior and bioavailability of paeonol were determined after a single intramuscular (i.m.) injection of 10 mg/kg to rats. Plasma paeonol concentrations were measured by high performance liquid chromatography (HPLC). The main pharmacokinetic parameters were as follows: mean elimination half-life (t1/2z) 59.85±10.23 min, time to reach peak concentration (Tmax) 7.50±2.74 min, maximum concentration (Cmax) 0.71±0.13 mg/1, total body clearance (CLz) 0.24±0.03 l/min/kg, the area under concentration-time curve from 0 to 4 h (AUC0–4h) 39.01±5.69 mg/l·min, the area under concentration-time curve from 0 to infinity (AUC0−∞) 43.06±6.10 mg/1·min. The absolute bioavailability of paeonol after i.m. administration amounted to 68.68%.

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Authors and Affiliations

  1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, 151 Malianwa North Road, Haidian District, 100193, Beijing, People’s Republic of China

    Li-Yan Ma, Xu-Dong Xu & Qi Zhang

  2. Guangxi Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Nanning, People’s Republic of China

    Jian-Hua Miao & Bing-Lan Tang

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  1. Li-Yan Ma
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  2. Xu-Dong Xu
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  3. Qi Zhang
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  4. Jian-Hua Miao
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  5. Bing-Lan Tang
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Ma, LY., Xu, XD., Zhang, Q. et al. Paeonol pharmacokinetics in the rat following i.m. administration. Eur. J. Drug Metabol. Pharmacokinet. 33, 133–136 (2008). https://doi.org/10.1007/BF03191109

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  • DOI: https://doi.org/10.1007/BF03191109

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