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The main role of vitamin D: Seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development

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References

  1. Stumpf W.E. (1988): Vitamin D-Soltriol. The heliogenic steroid hormone: somatotrophic activator and modulator. Discoveries from histochemical studies lead to new concepts. Histochemistry, 89:209–219.

    Article  CAS  PubMed  Google Scholar 

  2. Stumpf W.E. (1995): Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting. Histochemistry Cell Biol., 104:417–427.

    Article  CAS  Google Scholar 

  3. Stumpf W.E. (2005): Drug localization and targeting with receptor microscopic autoradiography. J. Pharmacol. Toxicol. Meth., 51:25–40.

    Article  CAS  Google Scholar 

  4. Kumar R. (2002): 1 Alpha, 25-dihydroxyvitamin D(3) — not just a calciotropic hormone. Nephron, 91:576–581.

    Article  CAS  PubMed  Google Scholar 

  5. Holick M.F. (2005): Vitamin D: Important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J., 98:1024–1027.

    Article  PubMed  Google Scholar 

  6. Dusso A.S., Brown A..J.., and Slatopolsky E. (2005): Vitamin D: Am. J. Physiol. Renal Physiol., 289:F8–28.

    Article  CAS  PubMed  Google Scholar 

  7. Christakos S., Dhawan P., Shen Q., Peng X., Benn B., and Zhong Y. (2006): New insights into the mechanisms involved in the pleiotropic actions of 1,25dihydroxyvitamin D3. Ann. NY Acad. Sci., 1068:194–203.

    Article  CAS  PubMed  Google Scholar 

  8. Jensen E.V., DeSombre E.R., Jungblut P.W., Stumpf W.E., and Roth L.J. (1969): Biochemical and autoradiographic studies of 3H-estradiol localization. In: Roth L.J., Stumpf W.E. (eds): Autoradiography of diffusible substances. Academic Press, New York, pp. 81–97.

    Google Scholar 

  9. Stumpf W.E., and Sar M. (1976): Autoradiographic localization of estrogen, androgen, progestin and glucocorticosteroid in target tissues and non-target tissues. In: Pasqualini J. (ed.), Receptors and mechanism of action of steroid hormones. Modern Pharmacology-Toxicology, vol. 8, pp. 41–84, New York: Marcel Dekker.

    Google Scholar 

  10. Kuhn T.S. (1970): The structure of scientific revolutions. University of Chicago Press, Chicago, 2nd edition.

    Google Scholar 

  11. Stumpf W.E. (2006): The dose makes the medicine. Drug Discov. Today, 11:550–555.

    Article  CAS  PubMed  Google Scholar 

  12. Stumpf W.E. (2003): Drug localization in tissues and cells. Chapel Hill: IDDC Press.

    Google Scholar 

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  1. Cytopharmacology and Cytotoxicology, University of North Carolina and International Institute of Drug Distribution, Chapel Hill, NC, USA

    Walter E. Stumpf

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  1. Walter E. Stumpf
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Stumpf, W.E. The main role of vitamin D: Seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development. Eur. J. Drug Metabol. Pharmacokinet. 32, 1–6 (2007). https://doi.org/10.1007/BF03190983

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  • DOI: https://doi.org/10.1007/BF03190983

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