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The effect of hydroxy metabolites of clarithromycin to the pharmacokinetic parameters, and determination of hydroxy metabolites ratio of clarithromycin

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A Correction to this article was published on 29 August 2020

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Summary

Clarithromycin is a broad-spectrum macrolide antibacterial agent which is effective bothin vitro andin vivo against the major pathogens responsible for respiratory tract infections. Clarithromycin’s principal metabolite is 14-(R) hydroxyclarithromycin (14-OH-clarithromycin). The other metabolite, namely 14-(S) hydroxyclarithromycin is inactive. The purpose of this study was to show the hydroxylation of CLA at the 14 position to form the R and S epimers and to determine the metabolic ratio of 14ROHCLA/CLA and 14SOHCLA/CLA for understanding the metabolization. This study suggest that in healthy adults, the individual variations in therapeutic responses to clarithromycin can be assumed by taking the drug and its metabolites ratios. Clarithromycin and metabolites ratios increase during metabolization.

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Change history

  • 29 August 2020

    The following article was unintentionally published twice in European Journal of Drug Metabolism and Pharmacokinetics.

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Authors and Affiliations

  1. GLP Laboratory and GCP Clinics, Yeditepe Health Service, Acibadem, İstanbul, Turkey

    Durisehvar Unal (Assoc. Prof.), Latif Ozbay, Banu Ozkirim & Dilek Erol

  2. Faculty of Medicine, Yeditepe University, Kayisdagi, İstanbul, Turkey

    Aysen Fenercioglu

  3. Faculty of Pharmacy, Yeditepe Health Service, GCP Clinic, Yeditepe University, Köftüncü Sokak. No: 1 Acibadem, 34178, Kadiköy, Istanbul, Turkey

    Durisehvar Unal (Assoc. Prof.), Latif Ozbay & Dilek Erol

Authors
  1. Durisehvar Unal
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  2. Aysen Fenercioglu
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  3. Latif Ozbay
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  4. Banu Ozkirim
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  5. Dilek Erol
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Unal, D., Fenercioglu, A., Ozbay, L. et al. The effect of hydroxy metabolites of clarithromycin to the pharmacokinetic parameters, and determination of hydroxy metabolites ratio of clarithromycin. Eur. J. Drug Metabol. Pharmacokinet. 33, 243–246 (2008). https://doi.org/10.1007/BF03190879

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  • DOI: https://doi.org/10.1007/BF03190879

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