Summary
The binding of racemic tertatolol and 4-hydroxytertatolol and of their enantiomers was compared in α1-acid glycoprotein and albumin solutions. The binding rate of S(-)tertatolol to α1-acid glycoprotein was much greater than that of R(+)tertatolol, the binding of the racemate being intermediate. It was the reverse for the binding to albumin, although the differences were slight. The binding of 4-hydroxytertatolol racemate and enantiomers was very low as compared to the binding of tertatolol, and there were no statistically significant differences in the binding of the 4-hydroxytertatolol enantiomers to either α1-acid glycoprotein or albumin.
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References
Leeamn M., Naeije R., Degaute J.P., Brackman F., Thomas J. Prost J.F. (1986): Tertatolol preserves renal perfusion in patients with arterial hypertension after head injury. Am. J. Nephrol., 6 (Suppl. 2), 36–39.
Smits J.F.M., Zeegers H.H.M. Struyker-Boudier H.A.J. (1989): Stereospecificity of α-adrenoceptor blockade and renal vasodilatation by tertatolol. Arch. Int. Pharmacodyn., 298, 164–171.
Urien S., Morin D., Renouard A., Rocher I. Tillement J.P. (1988): Variations in serum binding of tertatolol mediated by disease-induced modification of α1-acid glycoprotein concentration. Eur. J. Clin. Pharmacol., 34, 381–385.
Glasson S., Zini R. Tillement J.P. (1982): Multiple serum binding of two thienopyridinic derivatives, ticlopidine and PCR 2362, and their distribution between HSA, α1-acid glycoprotein and lipoproteins. Biochem. Pharmacol., 31, 831–835.
Urien S., Riant P., Renouard A., Coulomb B., Rocher I. Tillement J.P. (1988): Binding of indapamide to serum proteins and erythrocytes. Biochem. Pharmacol., 37, 2963–2966.
Walle U.K, Walle T., Bai S.A. Olanoff F.S. (1983): Stereoselective binding of propranolol to human plasma, α1-acid glycoprotein, and albumin. Clin. Pharmacol. Ther., 34, 718–723.
Albani F., Riva R., Contin M. Baruzzi A. (1984): Stereoselective binding of propranolol enantiomers to human α1-acid glycoprotein and human plasma. Br. J. Clin. Pharmacol., 18, 244–246.
Lima J J, Jungbluth G.L, Devine T. Robertson L.W. (1984): Stereoselective binding of disopyramide to human plasma protein. Life Sci, 35, 835–839.
Brunner F. Müller W.E. (1987): The stereoselectivity of the single drug binding site of human α-acid glycoprotein (orosomucoid). J. Pharm. Pharmacol, 39, 986–990.
Campbell D.B, Chignon J.C. Devissaguet J.P. (1986): Biodisposition of tertatolol in man: a review. Am. J. Nephrol., 6 (Suppl. 2), 61–68.
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Bastian, G., Urien, S., Brée, F. et al. Stereoselective binding of tertatolol and of 4-hydroxytertatolol to human plasma proteins. European Journal of Drug Metabolism and Pharmacokinetics 17, 233–236 (1992). https://doi.org/10.1007/BF03190151
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DOI: https://doi.org/10.1007/BF03190151