Summary
The metabolism of an oral dose of S-carboxymethyl-l-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-l-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electrochemical detection (ECD); the possibility of stereospecific sulphoxidation was investigated.
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References
Rogers ICM., Barnsley E.A. (1977): The metabolism of S-carboxymethylcysteine in man. Xenobiotica, 7, 409–414.
Waring R.H. (1978): The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans. Xenobiotica, 8, 265–270.
Tumbull L., Teng L., Kinzie J.M., Pitts J.E., Pinchbeck F.M., Bruce R.B. (1978): Excretion and biotransformation of carboxymethylcysteine in rat, dog, monkey and man. Xenobiotica, 8, 621–628.
Waring R.H. (1980): Variation in human metabolism of S-carboxymethylcysteine. Eur. J. Drug Metab. Pharmacokinet, 5, 49–52.
Waring R.H., Mitchell S.C., Idle J.R., Smith R.L. (1981) : Genetically determined impaired drug sulphoxidation. Lancet, April 748.
Waring R.H., Mitchell S.C., Shah R.R., Idle J.R., Smith R.L. (1982): Polymorphic sulphoxidation of S-carboxymethyl-l-cysteine in man. Biochem. Pharmacol., 31, 3151–3154.
Waring R.H., Mitchell S.C. (1982): The metabolism and elimination of S-carboxymethyl-l-cysteine in man. Drug Metab. Dispos., 10, 61–62.
Bray H.G., Caygill J.C., James S.P., Wood P.B. (1964): Metabolism of some halogenoparaffins and nitroparaffins. Biochem. J., 90, 127–132.
Woolfson A.D., Millership J.S., Karim El Fatih I.A. (1987): Determination of the sulphoxide metabolites of S-carboxymethyl-l-cysteine by high performance liquid chromatography with electrochemical detection. Analyst, 112, 1421–1426.
Synge R.L.M., Wood J.C. (1956): (+)-(S-methyl-l-cysteine S-oxide) in cabbage. Biochem. J., 64, 252–259.
Matheson N.A., Moir A.W. (1976): A simple method for the approximate determination of SMCO (Kale Anemia Factor). J. Sci. Food Agric, 27, 959–961.
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Fatih, E., Karim, I.A., Millership, J.S. et al. An investigation of the metabolism of S-carboxymethyl-l-cysteine in man using a novel HPLC-ECD method. Eur. J. Drug Metab. Pharmacokinet. 13, 253–256 (1988). https://doi.org/10.1007/BF03190087
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DOI: https://doi.org/10.1007/BF03190087