Summary
The plasma concentrations of repaglinide in 16 male subjects were determined after an oral dose of 4 mg. Two-peak concentrations in plasma were observed. A type of one-compartment model with double sites of drug absorption was developed and successfully used to fit the data. A good agreement between observed and predicted data was found in all subjects with correlation index r2 > 0.97. The corresponding pharmacokinetic parameters were estimated as follows: Tmax1 0.61 ±0.14 h, Tmax2 1.45±0.43 h, Cmax1 40.60±20.57 ng/ml, Cmax2 42.70±17.54 ng/ml, T1 0.12±0.07 h, T2 0.67±0.30 h and T3 1.03±0.35 h.
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Liu, X.D., Ji, H.F., Xie, L. et al. A double-site absorption model fits to pharmacokinetic data of repaglinide in man. Eur. J. Drug Metab. Pharmacokinet. 25, 115–119 (2000). https://doi.org/10.1007/BF03190077
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DOI: https://doi.org/10.1007/BF03190077