Summary
Twenty-two days after administration by intravenous bolus, of 50 mg of adriamycin to several patients we found concentrations of adriamycin and adriamycinol of the order of 100 pcg/ml. In theory, however, with a terminal half-life of 30 h, the plasma levels of adriamycin and adriamycinol should be close to 0.1 pcg/ml. Further pharmacokinetic investigation was therefore necessary.
We have retained for this study nine male patients, aged between 53 and 69 years who received 25 to 50 mg of adriamycin by slow intravenous injection. The HPLC method permitted the detection of 50 pcg/ml of adriamycin and adriamycinol, with the possibility of monitoring their elimination during 120 h (and in one case during 160 h).
The terminal half-lives of elimination estimated in 8 patients were respectively 110 ± 52 h for adriamycin and 92 h 50 min ± 43 h for adriamycinol. Surface ratios under adriamycinol curves against calculated adriamycin was 1.10 ± 0.26. Plasma levels found during the To in certain patients correspond to the end of the drug elimination of the previous treatment.
It is difficult with a half-life to 110 h to predict the effects of residual concentrations of adriamycin and adriamycinol.
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Taylor A.L., Applefeld M.M., Wiernik P.M., Grochow L.B., Mader L.C., Bulkey B.M. (1984): Acute anthracycline cardiotoxicity. Cancer, 75, 1660–1666.
Laurent S., Colbert N., Izrael V., Motte G. (1984): Cardiotoxicity of anthracycline. Ann. Int. Med., 6, 464–472.
Robert J. (1988): Pharmacokinetics of some new anthracycline antibiotics. Bull. Cancer, 75, 167–174.
Krarup-Hansen A., Wassermann K., Rasmussen S.D., Dalmark M. (1988): Pharmacokinetics of doxorubicin in man with induced acid or alkaline urine. Acta Oncologics, 27, 25–30.
Robert J. (1987): Pharmacokinetics and metabolism of anthracycline in human. Path. Biol., 35, 27–30.
Marty M., Espie M., Gisselbrecht C., Lagier G. (1987): Recent data on anthracyclines. Path. Biol., 35, 5–10.
Camaggi C.M., Comparai R., Strocchi E., Testoni F., Angelelli B., Pannuti F. (1988): Epimbicin and doxorubicin comparative metabolism and pharmacokinetics. Cancer Chemother. Pharmacol., 21, 221–228.
Mross K., Maessen P., Van der Vijgh W.J.F., Gall H., Boven E., Pinedo H.M. (1988): Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans. J. Clin. Oncol, 6, 517–526.
Leca F., Marchiset-Leca D., Antonetti M. (1989): A very sensitive HPLC method with fluorimetric detection for the determination of adriamycin and adriamycinol in human plasma. Chromatographia, 28, 375–378.
Robert J. (1980): Extraction of anthracyclines from biological fluids for HPLC evaluation. J. Liquid Chromatogr., 3, 1561–1572.
Speth P.A., Luissen P.C.M, Boezemarm J.B.M, Wessel H.M.C., Haanen C. (1987): Cellular and plasma adriamycin concentrations in long term infusion therapy of leukemia patients. Cancer Chemother. Pharmacol., 20, 305–310.
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Leca, F., Marcfflset-Leca, D., Noble, A. et al. New data on the pharmacokinetics of adriamycin and its major metabolite, adriamycinol. European Journal of Drug Metabolism and Pharmacokinetics 16, 107–111 (1991). https://doi.org/10.1007/BF03189946
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DOI: https://doi.org/10.1007/BF03189946