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In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

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Summary

The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

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Authors and Affiliations

  1. Instituto di Chimica Farmaceutica Applicate, Universita di Torino, C. so Raffaello 31, 10125, Torino, Italia

    O. Caputo, G. Grosa, G. Balliano, F. Rocco & G. Biglino

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  1. O. Caputo
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  2. G. Grosa
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  3. G. Balliano
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  4. F. Rocco
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  5. G. Biglino
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Caputo, O., Grosa, G., Balliano, G. et al. In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole. European Journal of Drug Metabolism and Pharmacokinetics 13, 47–51 (1988). https://doi.org/10.1007/BF03189928

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  • DOI: https://doi.org/10.1007/BF03189928

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