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Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat

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Summary

The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.

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Reference

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Authors and Affiliations

  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People’s Republic of China

    X. Han & X. Bao

  2. China Pharmaceutical University, 210009, Nanjing, People’s Republic of China

    N. Feng, Z. Zhang, D. An, W. Huang & G. Wang

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  1. N. Feng
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  2. Z. Zhang
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  3. D. An
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  4. W. Huang
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  5. G. Wang
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  6. X. Han
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  7. X. Bao
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Feng, N., Zhang, Z., An, D. et al. Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat. European Journal of Drug Metabolism and Pharmacokinetics 23, 41–44 (1998). https://doi.org/10.1007/BF03189825

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  • DOI: https://doi.org/10.1007/BF03189825

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