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An attempt to establish an in vitro-in vivo correlation: case of paracetamol immediate-release tablets

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Summary

The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.

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References

  1. Katori N., Aoyagi N., Terao T. (1995): Estimation of agitation intensity in the GI tract in humans and dogs based on in vitro in vivo correlation. Pharm. Res., 12, 237–243.

    Article  CAS  PubMed  Google Scholar 

  2. Ishii K., Saitou Y., Yamada R., Itai S., Nemoto M. (1996): Novel approach for determination of correlation between in vivo and in vitro dissolution using the optimization technique. Chem. Pharm. Bull., 44, 1550–1555.

    CAS  PubMed  Google Scholar 

  3. Mattok L.G., McGilveray I.J., Mainville A.C. (1971): Acetaminophen III: dissolution studies of commercial tablets of acetaminophen and comparison with in vivo absorption parameters. J. Pharm. Sci., 60, 561–564.

    Article  CAS  PubMed  Google Scholar 

  4. Sotiropoulus B.J., Deutsch T., Plakogiannis M.F. (1981): Comparative bioavailability of three commercial acetaminophen tablets. J. Pharm. Sci., 70, 422–425.

    Article  CAS  PubMed  Google Scholar 

  5. Forrest J.A.H., Clements J.A., Prescott L.F. (1982): Clinical pharmacokinetics of paracetamol. Clin. Pharmacokinet., 7, 93–107.

    Article  CAS  PubMed  Google Scholar 

  6. Sartorius dissolution simulator, Instruction manual. Sartorius GmbH, Götingen, Germany

  7. Brockmeier D. (1986). In vitro/in vivo correlation of dissolution using moments of dissolution and transit times. Acta Pharm. Technol., 32, 164–174.

    CAS  Google Scholar 

  8. Radovanović J., Durić Z., Jovanović M., Ibrić S., Nikolić L. (1997): The influence of pH and agitation intensity on drug release from tablets evaluated by means of factorial design, Presented at 16th Pharmaceutical Technology Conference, Athens, Greece, April, 15–17.

  9. Cardot J.M., Beyssac E. (1993): In vitro/in vivo correlations: scientific implications and standardisation. Eur. J. Drug Metab. Pharmacokinet., 18, 113–120.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physics, Faculty of Pharmacy, University of Belgrade, Belgrade, Yugoslavia

    M. Petrović

  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Yugoslavia

    J. Radovanović, Z. Durić, M. Jovanović & S. Ibrić

Authors
  1. J. Radovanović
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  2. Z. Durić
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  3. M. Jovanović
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  4. S. Ibrić
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  5. M. Petrović
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Radovanović, J., Durić, Z., Jovanović, M. et al. An attempt to establish an in vitro-in vivo correlation: case of paracetamol immediate-release tablets. European Journal of Drug Metabolism and Pharmacokinetics 23, 33–40 (1998). https://doi.org/10.1007/BF03189824

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  • DOI: https://doi.org/10.1007/BF03189824

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