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Bioavailability study of paracetamol tablets in saliva and urine

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Summary

A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.

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Authors and Affiliations

  1. Cátedra de Ensayo y Valoración de Medicamentos, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Casilla de Correos 243, 1900, La Plata, Argentina

    P. Retaco, M. González & M. G. Volonté

  2. Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina

    M. T. Pizzorno

Authors
  1. P. Retaco
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  2. M. González
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  3. M. T. Pizzorno
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  4. M. G. Volonté
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Retaco, P., González, M., Pizzorno, M.T. et al. Bioavailability study of paracetamol tablets in saliva and urine. European Journal of Drug Metabolism and Pharmacokinetics 21, 295–300 (1996). https://doi.org/10.1007/BF03189730

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  • DOI: https://doi.org/10.1007/BF03189730

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