Abstract
The localization and elimination of35S-Thiazolidine carboxylic acid has been studied in rats following a single oral dose (100 mg/kg) and multiple oral doses (100 mg/kg/day) over 15 days.
The compound was rapidly and completely absorbed as evaluated by the time of the maximum plasma35S-concentration (140 μg eq/ml at 30 min) and the amount of radioactivity in the feces (less than 1% of the dose over 48 h). Urinary excretion seems to be the unique route of elimination.
There was specific tissue accumulation of drug or metabolite, particularly in liver (29% of the dose at 3h), pancreas (7% of the dose at 3h), adrenals (320 μg eq/g at 3h), pituitary and thyroid (230 μg eq/g at 3h). Fixation of radioactivity appears significantly higher after chronic treatment than after acute treatment.
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Harmand, M.F., Blanquet, P. Pharmacokinetics and metabolism of [35S]-Thiazolidine carboxylic acid in the rat. I Elimination and distribution. European Journal of Drug Metabolism and Pharmacokinetics 7, 323–327 (1982). https://doi.org/10.1007/BF03189636
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DOI: https://doi.org/10.1007/BF03189636