Summary
After intraperitoneal administration of procyclidine, eight metabolites were isolated from rat urine. They were identified as l-(4-oxocyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-(cis-4-hydroxycyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, 1-(trans-4-hydrocyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, (1R*,3R*,4S*,7R*)- and ( 1R*,3R*,4S*, 7S*)-1-(cis-3,cis-4-dihydroxy-cyclohexyl)-1-phenyl-3-(1-pyrrolidinyl)-1-propanol, (1R*,3R*,4R*,7R*)- and (1R*,3R*,4R*, 7S*)-1-(cis-3,trans-4-dihydroxycyclo-hexyl)-l-phenyl-3-(l-pyrrolidinyl)-1-propanol, and one of both (1R*, 3S*, 4R*,7R*)- or (1R*, 3S*, 4R*, 7S*)-l-(trans-3, trans-4-dihydroxycyclohexyl)-1-phenyl-3-(l-pyrrolidinyl)-1-propanol by comparative TLC, GLC-MS andl3C-NMR spectroscopy.
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Paeme, G., Grimee, R. & Vercruysse, A. Isolation and identification of eight procyclidine metabolites from rat urine. European Journal of Drug Metabolism and Pharmacokinetics 9, 103–108 (1984). https://doi.org/10.1007/BF03189612
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DOI: https://doi.org/10.1007/BF03189612