Summary
Absorption, tissue distribution, excretion, protein binding, and the metabolism ofl4C labelled F-leurosine were studied in the rat. A triphasic curve for the disappearance of the drug from blood was found. The bile was the major route of excretion: 80% of radioactivity was recovered in the bile during the first 28 h after i.v. administration. 54% of the F-leurosine binds, in the concentration range of 0.1 umol/l-0.5 mmol/1 to plasma proteins. The TLC and HPLC data suggested that the bile of rats administered [14C]-F-leurosine contained either none or only small amount of metabolic products, which were most probably due to chemical decomposition rather then metabolism. Rat liver homogenates did not metabolize [14C] F-leurosine to any detectable extent.
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Ronai-Lukacs, S., Vereczkey, L. The pharmacokinetics and metabolism ofN-desmethyl-N-formyl-leurosine (F-leuruosine) in the rat. European Journal of Drug Metabolism and Pharmacokinetics 7, 47–53 (1982). https://doi.org/10.1007/BF03189542
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DOI: https://doi.org/10.1007/BF03189542