Summary
The problems of interpreting autoradiographs in which significant cross-fire occurs are considered. An analytical approach is proposed in which the tissue is ⥧odelled’ as a collection of items of uniform radioactivity. An iterative method of determining the best model is described and discussed briefly and its, advantages pointed out. They include avoidance of ’big computer’ programmes and facilitation of error computation.
Similar content being viewed by others
References
Blackett N.M. and Parry D.M. (1973): A new method for analysing electron microscope autoradiographs using hypothetical grain distributions. J.Cell Biol.,57, 9–15.
Nadler N.J. (1971): The interpretation of grain counts in electron microscope radioautography. J.Cell Biol.,49, 877–882.
Salpeter M.M., Bachmann L. and Salpeter E.E. (1969): Resolution in electron microscope radioautography. J.Cell Biol.,41, 1–20.
Salpeter M.M., Fertuck H.C. and Salpeter E.E. (1977): Resolution in electron microscope autoradiography III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters. J.Cell Biol.,72, 161–173.
Williams M.A. (1969): The assessment of electron microscopic autoradiographs. Advanc. Opt. Electr. Microsc,3, 219–272.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Downs, A., Williams, M.A. Analysis of autoradiographs in which cross-fire is significant. A new iterative method. European Journal of Drug Metabolism and Pharmacokinetics 3, 137–140 (1978). https://doi.org/10.1007/BF03189497
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03189497