Skip to main content
Log in

Analysis of autoradiographs in which cross-fire is significant. A new iterative method

  • Original Papers
  • Published:
European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

The problems of interpreting autoradiographs in which significant cross-fire occurs are considered. An analytical approach is proposed in which the tissue is ⥧odelled’ as a collection of items of uniform radioactivity. An iterative method of determining the best model is described and discussed briefly and its, advantages pointed out. They include avoidance of ’big computer’ programmes and facilitation of error computation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Blackett N.M. and Parry D.M. (1973): A new method for analysing electron microscope autoradiographs using hypothetical grain distributions. J.Cell Biol.,57, 9–15.

    Article  CAS  PubMed  Google Scholar 

  2. Nadler N.J. (1971): The interpretation of grain counts in electron microscope radioautography. J.Cell Biol.,49, 877–882.

    CAS  PubMed  Google Scholar 

  3. Salpeter M.M., Bachmann L. and Salpeter E.E. (1969): Resolution in electron microscope radioautography. J.Cell Biol.,41, 1–20.

    Article  CAS  PubMed  Google Scholar 

  4. Salpeter M.M., Fertuck H.C. and Salpeter E.E. (1977): Resolution in electron microscope autoradiography III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters. J.Cell Biol.,72, 161–173.

    Article  CAS  PubMed  Google Scholar 

  5. Williams M.A. (1969): The assessment of electron microscopic autoradiographs. Advanc. Opt. Electr. Microsc,3, 219–272.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Downs, A., Williams, M.A. Analysis of autoradiographs in which cross-fire is significant. A new iterative method. European Journal of Drug Metabolism and Pharmacokinetics 3, 137–140 (1978). https://doi.org/10.1007/BF03189497

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03189497

Key-words

Navigation