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In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine

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Summary

Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule.

Itsin vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified : dibenzo [c,f]-[1,2]diazepine-l-N-oxide and a monohydroxyderivative in the aromatic ring.

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Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea, 62, 20157, Milan, Italy

    A. Frigerio, P. Negrini, L. Cappellini, D. Rotilio, A. De Pascale & E. Rossi

Authors
  1. A. Frigerio
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  2. P. Negrini
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  3. L. Cappellini
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  4. D. Rotilio
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  5. A. De Pascale
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  6. E. Rossi
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Frigerio, A., Negrini, P., Cappellini, L. et al. In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine. European Journal of Drug Metabolism and Pharmacokinetics 4, 35–41 (1979). https://doi.org/10.1007/BF03189397

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  • DOI: https://doi.org/10.1007/BF03189397

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