Summary
The metabolism of nealbaxbitone (I) and allylisobutylbarbituric acid (III) has been studied in normal human volunteers. The urinary excretion of parent drugs, and derived diols, was studied following multi-dose administration at normal therapeutic dose levels, and the kinetics of excretion discussed in terms of the various ring opening routes available to the epoxide intermediates.
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Gilbert, J.N.T., Powell, J.W. Multidose studies in the human metabolism of two allyl barbiturates. European Journal of Drug Metabolism and Pharmacokinetics 3, 195–203 (1978). https://doi.org/10.1007/BF03189384
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DOI: https://doi.org/10.1007/BF03189384