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Comparative bioavailability study of codeine and ibuprofen after administration of the two products alone or in association to 24 healthy volunteers

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Summary

The study objective was to compare the bioavailability of codeine and ibuprofen after oral administration of the two drugs alone or in association. The study was performed in three different periods, each separated by a wash-out of 6 days. Plasma concentrations were measured in 24 healthy volunteers after administration of a single oral dose of codeine phosphate (25 mg) and/or ibuprofen (200 mg). Codeine and ibuprofen assays were performed using two different HPLC methods.

The relative bioavailabilities of codeine and ibuprofen (alone or in association) were 106±24% (mean±sd) and 101±19%, respectively. The results obtained demonstrated that bioavailabilities of codeine and ibuprofen were not modified when the two drugs were administrated alone or in association.

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Authors and Affiliations

  1. Adme Bioanalyses, Parc Haute Technologie, 694 Avenue du Dr. Donat, 06250, Mougins, France

    J P Laneury & P. Duchene

  2. Institut de Recherche Pierre Fabre, Centre de Développement Pharmaceutique de Vigoulet, 31222, Castanet Tolosan, France

    P. Hirt, A. Delarue & S. Gleizes

  3. Laboratoire de Pharmacocinétique et de Toxicologie Clinique, CHU de Rangueil, 1 Avenue Jean Poulhès, 31054, Toulouse, France

    G. Houin

  4. Therapharm Recherches, 59 Rue de Billancourt, 92100, Boulogne-Billancourt, France

    P. Molinier

Authors
  1. J P Laneury
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  2. P. Duchene
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  3. P. Hirt
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  4. A. Delarue
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  5. S. Gleizes
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  6. G. Houin
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  7. P. Molinier
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Laneury, J.P., Duchene, P., Hirt, P. et al. Comparative bioavailability study of codeine and ibuprofen after administration of the two products alone or in association to 24 healthy volunteers. European Journal of Drug Metabolism and Pharmacokinetics 23, 185–189 (1998). https://doi.org/10.1007/BF03189337

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  • DOI: https://doi.org/10.1007/BF03189337

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