Summary
Plasma levels of dichloro-2,3 (thienyl-2 keto)-4 phenoxyacetic acid in the dog are determinated by a spectrophotometric method. The detection limit of tienilic acid is 2±0,2 fig in one ml plasma or urine.
After oral administration of tienilic acid to dogs a biological half life of 75+-23 minutes can be calculated, based on plasma level data. The urinary excretion of dichloro-2,3 (thienyl-2 keto)-4 phenoxyacetic acid in 8 hours is about 9 % of the dose.
A metabolite, dichloro-2,3 (thienyl-2 carbinol)-4 phenoxyacetic acid is found in plasma and urine, indicating the metabolic reduction of the keto function.
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Maurer, G., Roche, M., Darmenton, P. et al. Biological half life and metabolism of a new diuretic, dichloro-2,3 (thienyl-2 keto)-4 phenoxyacetic acid, in the dog. European Journal of Drug Metabolism and Pharmacokinetics 1, 202–205 (1976). https://doi.org/10.1007/BF03189279
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DOI: https://doi.org/10.1007/BF03189279