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Mutagenic effects of certain common metal toxicants on mammalian systems

  • Published:
Proceedings: Animal Sciences

Abstract

The use of metals for human benefit started more than 6000 years ago. Their harmful effects were noted much later, with the growing consciousness about environmental hazards. The different industrial processes and other adjuncts of industrial revolution have added considerably to the quantities of such metal occurring under natural conditions. An appreciable proportion enters into the formation of aerosols, known to be toxic to living systems. Assessment of the hazards posed by metal effluents and their mode of action are therefore gaining considerable importance as a part of environment protection.

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References

  • Anonymous 1973 Increased heavy metals around Sudbury’s smelters;Water Pollu. Control 111 48–49

  • Axtmann R C 1975 Environmental impact of a geothermal power plant;Science 186 795–803

    Google Scholar 

  • Baader E W 1937 BerufskrebsNeuere Ergebnisse auf dem Gebiete der Rrebsrankheiten, C Adam andD Auter, (eds) S Hirzel Verlag, Leipzig pp. 116–117

    Google Scholar 

  • Baker D E and Chesnin L 1976 Chemical monitoring of soils for environmental quality and animal and human health;Adv. Agron. 27 305

    Google Scholar 

  • Banerjee R, Giri A K, Talukder G and Sharma A 1979 Effects of cobalt and nickel on mammalian cellular systems;Indian J. Environ. Health (in press)

  • Barnett G P 1949Annual Report of the Chief Inspector of Factories and Workshops for the year 1948. H.M. Stationery Office, London p. 229

    Google Scholar 

  • Basrur P K and Gilman J P W 1963 Behaviour of two cell strains derived from rat rhabdomyosarcomas;J. Natl. Cancer Inst. 30 163–200

    CAS  PubMed  Google Scholar 

  • Basrur P K and Gilman J P W 1967 Morphologic and synthetic response of normal and tumor muscle cultures to nickel sulfide;Cancer Res. 27 1168–1177

    CAS  PubMed  Google Scholar 

  • Bateman L B 1966 Testing chemicals for mutagenicity in a mammal;Nature (London) 210 205–206

    CAS  Google Scholar 

  • Beach D J and Sunderman F W Jr 1969 Nickel carbonyl inhibition of14C-orotic acid incorporation into rat liver RNA;Proc. Soc. Exp. Biol. Med. 131 321–322

    CAS  PubMed  Google Scholar 

  • Beach D J and Sunderman F W Jr 1970 Nickel carbonyl inhibition of RNA synthesis by a chromatin-RNA polymerase complex from hepatic nuclei;Cancer Res. 30 1645–1650

    Google Scholar 

  • Beskid M 1963 The effect of administration of cobalt chloride on the pancreas in the guinea-pig;Folia Histochem. Cytochem. 1 95–102

    CAS  Google Scholar 

  • Beskid M 1967 The action of cobalt on kidneys of the guinea-pig;Folia Histochem. Cytochem. 5 33–72

    CAS  Google Scholar 

  • Blot W J and Fraumeni J F Jr 1975 Arsenical air pollution and lung cancer;Lancet 2 142–144

    CAS  PubMed  Google Scholar 

  • Bourasset A and Galland G 1966 Cancer des voies respiratoires et exposition aux sels de nickel;Arch. Malad. Prof. 27 227–229

    CAS  Google Scholar 

  • Boyd G S and Maclean N 1959 Observations on the metabolic and histological effect of cobalt chloride in the rabbit, with particular reference to cobalt induced hypercholesterolaemia;Q. J. Exp. Physiol. 44 394–403

    CAS  Google Scholar 

  • Bremuer I 1974 Heavy metal toxicities;Quant. Rev. Biophys. 7 75

    Google Scholar 

  • Bridge J C 1933Annual report of the chief inspector of factories and workshops for the year 1932; H. M. Stationery Office, London pp. 103–104

    Google Scholar 

  • Brown M N, Rhyne B C, Goyer R A and Fowler B A 1976 Intracellular effects of chronic arsenic administration on renal proximal tubule cells;J. Toxicol. Environ. Health 1 505–514

    CAS  PubMed  Google Scholar 

  • Browning E 1969Toxicity of Industrial Metals 2nd ed (London: Butterworth and Co.)

    Google Scholar 

  • Bruce D W, Hietbrink B E and DuBois K P 1963 The acute mammalian toxicity of rare earth nitrates and oxides;Toxicol. Appl. Pharmacol. 5 750–759

    CAS  PubMed  Google Scholar 

  • Burgdorf W, Kurnvink K and Cervenka J 1977 Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic;Human. Genet. 36 69

    CAS  Google Scholar 

  • Campbell J A 1943 Lung tumours in mice and man;Br. Med. J. 1 179–183

    PubMed  Google Scholar 

  • Chakrabarty D, Bhattacharyya A, Majumdar K and Chatterjee G C 1977 Effect of chronic vanadium pentoxide administration on L-ascorbic acid supplementation;Int. J. Vit. Nutri. Res. 47 81–87

    Google Scholar 

  • Chisolm J J Jr 1970 Poisoning due to heavy metals;Pediatr. Clin. North Am. 17 591–615

    PubMed  Google Scholar 

  • Clayton C C and Baumann C A 1949 Diet and azo dye: Effect of diet during a period when the dye is not fed;Cancer Res. 9 575–582

    CAS  PubMed  Google Scholar 

  • Creutzfeld W and Schmidt W 1954 Uber die wirkung von Kobaltchlorid auf den Blutzucker und die Pankreasinseln bei verschiedenen Nagetieren;Arch. Exp. Pathol. Pharmakol. 222 487–512

    Google Scholar 

  • Cummins C M and Kimura E T 1971 Safety evaluation of selenium sulfide antidandruff shampoos;Toxicol. Appl. Pharmacol. 20 89–96

    CAS  PubMed  Google Scholar 

  • Curran G L, Azarnoff D L and Bolinger R E 1959 Inhibition of cholesterol synthesis from labelled acetate;J. Clin. Invest. 38 1251–1255

    CAS  PubMed  Google Scholar 

  • DeDuve C 1959 Lysosomes, a new group of cytoplasmic particles. The Fifth Annual Symposium Publication of the Society of General Physiologists; 128–160

  • DeDuve C 1963The lysosome concept. CIBA Foundation Symposium, Lysosomes (London: Churchill Ltd.) 1–35

    Google Scholar 

  • Deeths T M and Breeden J T 1971 Poisoning in children—A statistical study of 1057 cases;J. Pediatr. 78 299–305

    CAS  PubMed  Google Scholar 

  • De Master, E G and Mitchell R A 1970 The insensitivity of mitochondrial catalysed arsenate-water oxygen exchange reaction to dinitrophenol and to oligomycin;Biochem. Biophys. Res. Commun. 38 199–203

    Google Scholar 

  • Dingle J T, Heath J C, Webb M and Daniel M 1962 The biological action of cobalt and other metals;Biochem. Biophys. Acta 65 34–46

    CAS  PubMed  Google Scholar 

  • Dobson R L and Pinto J S 1966 Arsenical carcinogenesis; inAdvances in biology of skin, eds W Montagna and R L Dobson (New York: Pergamon Press)8 237–245

    Google Scholar 

  • Doll R, Morgan L G and Speizer F E 1970 Cancers of the lung and nasal sinuses in nickel workers,Brit. J. Cancer 24 623–632

    CAS  PubMed  Google Scholar 

  • Done A K and Pearl A J 1971 Acute toxicities of arsenical herbicides;Clin. Toxicol. 4 343–355

    CAS  PubMed  Google Scholar 

  • Drake J W and Baltz R H 1976 The biochemistry of mutagenesis;Ann. Rev. Biochem. 45 11–37

    CAS  PubMed  Google Scholar 

  • Dubois K P, Moxon A L and Olson O E 1940 Further studies on the effectiveness of arsenic in preventing selenium poisoning;J. Nutr. 19 477–482

    CAS  Google Scholar 

  • Dunn T B 1948 Sex differences in the alkaline phosphatase distribution in the kidney of the mouse;Am. J. Pathol. 24 719–720

    CAS  PubMed  Google Scholar 

  • Ehlers G 1974 Klinische und histologische untersuchungen zur Frage arzneimittelbedingter Arsen-tumoren;Z. Haut. Geschlechtskr. 43 763–774

    Google Scholar 

  • Eiji H 1955 Infant arsenic poisoning by powdered milk;Nihon iji Shimpo No. 1649 3–12

  • Epstein S S and Shafner H 1968 Chemical mutagens in the human environment;Nature (London) 219 385–386

    CAS  Google Scholar 

  • Fairhill L T, Dunn R D, Sharpless N E and Prichard E A 1945 Toxicity of molybdenum;U.S. Pub. Health Serv. Bull. 293 196–208

    Google Scholar 

  • Faulkner-Hudson T G 1964 Vanadium: Toxicology and biological significance;Elsevier Monographs on Toxic Agents, (Amsterdam: Elsevier Publishing Co.)

    Google Scholar 

  • Federal Register 1974 Selenium39 1355–1358

  • Fischler F and Roeckl K W 1938 Naunyn-Schmiedeberg’s;Arch. Exp. Pathol. Pharmakol. 189 4–12

    CAS  Google Scholar 

  • Forth W and Rummel W 1971 Absorption of iron and chemically related metalsin vitro andin vivo: Specificity of the iron binding system in the mucosa of the jejunum; inIntestinal absorption of metal ions, trace elements and radionuclides (eds) S C Skoryna and D Waldron-Edward (Oxford: Pergamon Press)

    Google Scholar 

  • Fowler B A 1974 The morphologic effects of mercury, cadmium, lead and arsenic on the kidney; inTrace metals in water supplies: Occurrence, significance and control. Proceeding Sixteenth Water Quality Conf. Champaign-Urbana: Department of Engineering, University of Illinois, Illinois, USA, pp. 65–76

  • Fowler B A 1975 The ultrastructural and biochemical effects of arsenate on the kidney;Proc. XVIII Int. Congr. Occup. Health Brighton, U.K.

  • Fowler B A and Weissberg J B 1974 Arsine poisoning;N. Engl. J. Med. 291 1171–1174

    CAS  PubMed  Google Scholar 

  • Foy C D, Chaney R L and White M C 1978 The physiology of metal toxicity in plants,Ann. Rev. Plant Physiol. 29 511

    CAS  Google Scholar 

  • Friedrich E G Jr 1972 Vulvar carcinomain situ in identical twins—an occupational hazard;Obstet. Gynecol. 39 837–841

    PubMed  Google Scholar 

  • Frust A and Schlauder M C 1971 The hamster as a model for carcinogenesis;Proc. West. Pharmacol. Soc. 14 68–71

    Google Scholar 

  • Fukina A M and Kudryavtseva T P 1969Mikroelem Med. Zhivotnovod, ed. M Kruming (USSR: Elm Baku) 1970Chem. Abstr. 73 129114B

    Google Scholar 

  • Gabbedy B J 1970 Toxicity in sheep associated with the prophylactic use of selenium;Aust. Vet. J. 46 223–226

    CAS  PubMed  Google Scholar 

  • Gardiner M R and Nicol H 1971 Cobalt-selenium interactions in the nutrition of rat;Aust. J. Exp. Biol. Med. Sci. 49 291–296

    CAS  PubMed  Google Scholar 

  • Gilman J P W 1962 Metal carcinogenesis. II. A study on the carcinogenic activity of cobalt, copper, iron and nickel compounds;Cancer Res.,22 158–165

    CAS  PubMed  Google Scholar 

  • Giri A K, Sharma A and Talukder G 1978 Cytochemical effects of cobalt sulphate and ceric sulphate on mammalian system;Bull. Inst. P.G. Med. Edu. Res. 20 145–147

    Google Scholar 

  • Giri A K, Banerjee R, Talukder G and Sharma A 1979 Effects of some trace elements on mammalian systems;Indian J. Exp. Biol. (in press)

  • Glendening B L, Schrenk W G and Parrish D B 1956 Effect of rubidium in purified diet rats;J. Nutr. 60 563–569

    CAS  PubMed  Google Scholar 

  • Gmelin C G 1826 Experiences sur l’action de la baryte, de la strontiane, du chrome, du molybdene, du tungstene, du tellure, de l’osmium, du platine, de l’iridium, du rhodium, du palladium, du nickel, du cobalt, de l’urane, du cerium, du feret, du manganese sur l’organisme animal;Bull. Sci. Med. 7 110–117

    Google Scholar 

  • Goldman A L 1973 Lung cancer in Bowen’s disease;Am. Rev. Respir. Dis. 108 1205–1207

    CAS  PubMed  Google Scholar 

  • Goyer R A and Mehlman M A 1976Toxicity of trace elements. (Washington: Hemisphere Publishing Co.)

    Google Scholar 

  • Grace J G, Garst E L and Lowry W E 1957 Comparative toxicity of stable rare earth compounds;Arch. Ind. Hyg. Occup. Med. 15 9

    Google Scholar 

  • Grunicke H, Bock K, Becker H, Gang V, Schnierda J and Puschendorf B 1973 Effect of alkylating antitumor agents on the binding of DNA to protein;Cancer Res. 33 1048–1053

    CAS  PubMed  Google Scholar 

  • Halverson A W, Tsay D T, Triebwasser K C and Whitehead E I 1970 Development of hemolytic anemia in rats fed selenite;Toxicol. Appl. Pharmacol. 17 151–159

    CAS  PubMed  Google Scholar 

  • Harr J R and Muth O H 1972 Selenium poisoning in domestic animals and its relationship to man;Clin. Toxicol. 5 175–184

    CAS  PubMed  Google Scholar 

  • Harr J R, Exon J H, Whanger P D and Weswig P H 1972 Effect of dietary selenium on N-2-fluroenyl acetamide (FAA)-induced cancer in vitamin E supplemented selenium depleted rats;Clin. Toxicol. 5 187–194

    CAS  PubMed  Google Scholar 

  • Harr J R, Exon J H, Weswig P H and Whanger P D 1973 Relationship of dietary selenium concentration, chemical cancer induction and tissue concentration of selenium in rats;Clin. Toxicol. 6 487–495

    CAS  PubMed  Google Scholar 

  • Hart R W, Hall K Y and Daniel F B 1979 DNA repair and mutagenesis in mammalian cells;Proc. Symp. 5th Ann. meeting of Amer. Soc. Photobiology (Puerto Rico: Pergamon)

  • Heath J C and Daniel M R 1964 The production of malignant tumors by nickel in rat;Br. J. Cancer. 18 251–264

    Google Scholar 

  • Heath J C and Webb M 1967 Content and intracellular distribution of the inducing metal in the primary rhabdomyosarcomata induced in the rat by cobalt, nickel and cadmium;Br. J. Cancer 21 768–774

    CAS  PubMed  Google Scholar 

  • Heath J C, Freedman M A R and Swanson S A V 1971 Carcinogenic properties of wear particles from prostheses made in cobalt-chromium alloy;Lancet 1 564–566

    CAS  PubMed  Google Scholar 

  • Hollstein M, McCann J, Angelosanto F A and Nichols W W 1979 Short-term tests for carcinogens and mutagens;Mutat. Res. 65 133–226

    CAS  PubMed  Google Scholar 

  • Holmberg R E and Ferm V H 1969 Interrelationships of selenium, cadmium, and arsenic in mammalian teratogenesis;Arch. Environ. Health 18 873–877

    CAS  PubMed  Google Scholar 

  • Holmes C W, Slade E A and Mclessan C J 1974 Migration and redistribution of zinc and cadmium in marine estuarine systems;Environ. Sci. Technol. 3 255

    Google Scholar 

  • Hood R and Bishop S L 1972 Teratogenic effects of sodium arsenate in mice;Arch. Environ. Health 24 62–65

    CAS  PubMed  Google Scholar 

  • Huebner R J and Todaro G J 1969 Oncogenes of RNA tumor viruses as determinants of cancer;Proc. Nat. Acad. Sci. 64 1087–1091

    CAS  PubMed  Google Scholar 

  • Hueper W C 1952 Experimental studies in metal carcinogenesis. I. Nickel cancer in rats;Tex Rep. Biol. Med. 10 167–186

    CAS  PubMed  Google Scholar 

  • Hueper W C 1955 Experimental studies in metal carcinogenesis. IV. Cancer produced by parentally introduced metallic nickel;J. Nat. Cancer Inst. 16 55–67

    CAS  PubMed  Google Scholar 

  • Hueper W C 1958 Experimental studies in metal carcinogenesis IX. Pulmonary lesions in guinea-pigs and rats exposed to prolonged inhalation of powdered metallic nickel;Arch. Pathol. 65 600–607

    CAS  Google Scholar 

  • Isom G E and Way J L 1974 Alteration ofin vivo glucose metabolism by cobaltous chloride;Taxicol. App. Pharmacol. 27 131–139

    CAS  Google Scholar 

  • Jackson D E 1912 The pulmonary action of vanadium together with a study of the peripheral reaction to the metal;Pharmacol. Exp. Ther. 4 1–10

    Google Scholar 

  • Jaffe W G, Mondragon M C, Layrisse M and Ojeda A A 1972 Toxicity symptoms in rats fed organic selenium;Arch. Latin Am. Nutr. 22 467–474

    CAS  Google Scholar 

  • Jung E 1969 Arsenic as an inhibitor of the enzymes concerned in cellular recovery (dark repair);Ger. Med. Mon. 14 614–616

    CAS  PubMed  Google Scholar 

  • Jung E 1971 Molecular biological investigation of chronic arsenic poisoning;Z. Haut-Geschlechtskr. 46 35–36

    Google Scholar 

  • Jung E G and Trachsel B 1970 Molekularbiologische Untersuchungen zur Arsencarcinogenese;Arch. Klin. Exp. Derm. 237 819–826

    CAS  PubMed  Google Scholar 

  • Jungmann R A and Schweepe J S 1972 Binding of chemical carcinogens to nuclear proteins of rat liver;Cancer Res. 32 952–959

    CAS  PubMed  Google Scholar 

  • Kanisawa M and Schroeder H A 1967 Life-term studies on the effects of arsenic, germanium, tin and vanadium on spontaneous tumors in mice;Cancer Res. 27 1192–1195

    CAS  PubMed  Google Scholar 

  • Karantassis T 1924 Sur la toxicite des compases du Tungstene eh du Molybdene;Bull. Csi Pharmacol. 31 561–564

    CAS  Google Scholar 

  • Kilbey B J, Legator M, Nichols W W and Ramel C 1977 (eds)Handbook of mutagenicity test procedures (Amsterdam: Elsevier)

    Google Scholar 

  • Kulieva T K 1971 Effect of vanadium on leukocytic activities in guinea-pig;Izv. Akad. Nauk. Turkm. SSR Ser. Biol. Nauk 3 70–71

    Google Scholar 

  • Lan T J, Hackett R L and Sunderman F W Jr 1972 The carcinogenicity of intravenous nickel carbonyl in rats;Cancer Res. 32 2253–2258

    Google Scholar 

  • Lee A M and Fraumeni J F 1969 Arsenic and respiratory cancer in man: An occupational study;J. Nat. Cancer Inst. 42 1045–1052

    CAS  PubMed  Google Scholar 

  • Levander O A and Argett L C 1969 Effect of arsenic, mercury, thallium and lead on selenium metabolism in rats;Toxicol. Appl. Pharmacol. 14 308–314

    CAS  PubMed  Google Scholar 

  • Levy H, Levison V and Schade A L 1950 The effect of cobalt on the activity of certain enzymes in homogenates of rat tissue;Arch. Biochem. 27 34–40

    CAS  PubMed  Google Scholar 

  • Liquier-Milward J 1951 Evidence of a complex compound of cobalt with a purine base (adenine);Nature 167 1068–1069

    CAS  PubMed  Google Scholar 

  • Lo L W, Koroptanick J and Stick H F 1978 The mutagenecity or cytotoxicity of selenite, “activated” selenite and selenate for normal and DNA repair deficient human fibroblast;Mutat. Res. 49 305–312

    CAS  PubMed  Google Scholar 

  • Loken A C 1950 Lungecarcinom hos nikkelanbeidere,Tidsskr. Nor. Laegeforen. 70 376–378

    CAS  PubMed  Google Scholar 

  • Loken A C 1956 Personal communication cited by Goldblatt M W and Goldblatt J:Occupational carcinogenesis: Nickel industrial medicine and hygiene ed E R A Merewether (London: Butterworth and Co.) p. 205

    Google Scholar 

  • Mann P J G, Tennenbaum M and Quastel H J 1939 Acetyl cholinemetabolism in C.N.S.;Biochem. J. 133 822

    Google Scholar 

  • Mastromatteo E 1967 Nickel: A review of its occupational health aspects;J. Occup. Med. 9 127–136

    CAS  PubMed  Google Scholar 

  • Maynard L S 1958 The influence of sulphydryl groups and their inhibitors on the distribution of radio cobalt in the organs and intracellular organelles of the mouse;Ann. N.Y. Acad. Sci. 72 229–237

    CAS  PubMed  Google Scholar 

  • Meekes M J, Landolt R R, Kessler W V and Born G S 1971 Effect of vanadium on metabolism of glucose in the rat;J. Pharmacol. Sci. 60 482

    Google Scholar 

  • Meltzer H L and Leibermann K W 1971 Chronic ingestion of rubidium without toxicity: Implications for human therapy;Experientia 27 672–674

    CAS  PubMed  Google Scholar 

  • Miles J R W 1968 Arsenic residues in agricultural soils of South-Western Ontario;J. Agric. Food. Chem. 16 620–622

    CAS  Google Scholar 

  • Milham S Jr and Strong T 1974 Human arsenic exposure in relation to a copper smelter;Environ. Res. 7 176–182

    CAS  Google Scholar 

  • Miller J A and Miller E C 1971 Chemical carcinogenesis: mechanisms and approaches to its control;J. Nat. Cancer Inst. 47 5–14

    Google Scholar 

  • Minkowitz S 1964 Multiple carcinomata following ingestion of medicinal arsenic;Ann. Intern. Med. 61 296–299

    CAS  PubMed  Google Scholar 

  • Mitchell D F, Shankwalker G B and Shazer S 1960 Determining the tumorigenicity of dental materials;J. Dent. Res. 39 1023–1028

    CAS  PubMed  Google Scholar 

  • Mitchell R A, Chang B F, Huang C H and DeMaster E G 1971 Inhibition of mitochondrial energy-linked functions by arsenate. Evidences for a nonhydrolytic mode of inhibitor action;Biochemistry 10 2049–2053

    CAS  PubMed  Google Scholar 

  • Molfino F 1938 Contributi sperimentalle allo studio dell’ intoxicazione professionale da vanadio;Rass. Med. Ind. 9 362–667

    CAS  Google Scholar 

  • Mountain J T, Delker L L and Stokinger H E 1953 Studies in vanadium toxicity;Arch. Ind. Hyg. Occup. Med. 8 406–411

    CAS  Google Scholar 

  • Moxon A L and Dubois K P 1939 The influence of arsenic and other elements on the toxicity of seleniferous grains;J. Nutr. 18 447–457

    CAS  Google Scholar 

  • Nagai H, Okuda R, Nagami H, Yagi A, Mori C and Wada H 1956 Subacute-chronic arsenic poisoning in infants—subsequent clinical observations;Shonika Kiyo 2 124–132

    Google Scholar 

  • Nakamura K, Yoshikawa K, Sayato Y, Kurata H, Tonomura M and Tonomura A 1976 Studies of selenium related compounds. V. Cytogenetic effect of reactivity with DNA;Mutat. Res. 40 177–183

    Google Scholar 

  • National Institute for occupational safety and health 1973Criteria for a recommended standard: Occupational exposure to inorganic arsenic (Washington: U.S. Department of Health, Education and Welfare)

    Google Scholar 

  • Nelson A A, Fitzhugh O G and Calvery H O 1943 Liver tumors following cirrhosis caused by selenium in rats;Cancer Res. 3 230–236

    CAS  Google Scholar 

  • Neubauer O 1947 Arsenical cancer: A reviewcancer Res. 1 192–251

    CAS  Google Scholar 

  • Nordenson I, Beckman G, Beckman L and Nordiström S 1978 Occupational and environmental risks in and around a smelter in northern Sweden. II. Chromosomal aberrations in workers exposed to arsenic;Hereditas 88 47

    CAS  PubMed  Google Scholar 

  • Novikoff A B 1962 Lizosomy a fizjologia i patologia Komorek;Folia Morphol 12 275–279

    Google Scholar 

  • Novikoff A B, Beautay H and De Duve C 1956 Electron microscopy of lysosome-rich fractions from rat liver;J. Biophys. Biochem. Cytol. 2 179–184

    PubMed  CAS  Google Scholar 

  • Olinici C D, Risca R and Todorutiu C 1973 Cytogenetic observations of nickel-induced tumors in mice;Oncol. Radiol. 12 41–46

    CAS  Google Scholar 

  • Ott M, Holder B B and Gordon H L 1974 Respiratory cancer and occupational exposure to arsenicals;Arch. Environ. Health 29 250–255

    CAS  PubMed  Google Scholar 

  • Palmer I S and Bonhorst C W 1957 Modification of selenite metabolism by arsenite;J. Agric. Food. Chem. 12 928–930

    Google Scholar 

  • Passey R D 1962 Some problems of lung cancer;Lancet 2 107–112

    CAS  PubMed  Google Scholar 

  • Paton G R and Alison A C 1972 Chromosome change in human cell cultures induced by metal salts;Mutat. Res. 16 332–336

    CAS  PubMed  Google Scholar 

  • Pedersen E, Hogetveit A C and Cauderson A 1973 Cancer of respiratory organs among workers at a nickel refinery in Norway;Int. J. Cancer 12 32–41

    CAS  PubMed  Google Scholar 

  • Petres J and Hundeiker M 1968 Chromosome pulverization inducedin vitro in cell cultures by sodium diarsenate.Arch. Klin. Exp. Dermatol. 231 366–370

    CAS  PubMed  Google Scholar 

  • Petres J, Schmid-Ullrich K and Wolf U 1970 Chromosomenaberrationen an menschlichen Lymphozytem bei chronischen Arsenschaden;Dtsche Med. Wochenchr. 95 79–82

    CAS  Google Scholar 

  • Purves D 1972 Consequences of trace elment contamination of soils;Environ. Pollut. 3 17

    CAS  Google Scholar 

  • Riley J F 1968 Mast cells, co-carcinogenesis and anticarcinogenesis in the skin of mice;Experientia 24 1237

    CAS  PubMed  Google Scholar 

  • Robertson D S E 1970 Selenium—a possible teratogen;Lancet 1 518–519

    CAS  PubMed  Google Scholar 

  • Rockstroh H 1958 Zur Atiologie des Bronchialkrebs in arsenverarbeitenden Nickel-hutten;Arch. Geshneulstforsch. 14 151–162

    Google Scholar 

  • Rona G 1971 Experimental aspects of cobalt cardiomyopathy;Br. Heart J. 33 171–174

    PubMed  Google Scholar 

  • Rosenfeld I and Beath O A 1964Selenium (New York: Academic Press)

    Google Scholar 

  • Roshchin I V 1963Toxicology of the rare metals ed. Z I Izraelson, AEC-tr-6710 (Washington: Atomic Energy Commission)

    Google Scholar 

  • Roshchin I V 1967 Toxicology of vanadium compounds used in modern industry;Gig. i. Sanit. 32 26–34

    CAS  Google Scholar 

  • Ryser H J P 1971 Chemical carcinogenesis;New Eng. J. Med. 285 721–734

    Article  CAS  PubMed  Google Scholar 

  • Sabedell J E and Axtmann R C 1975 Heavy metal contamination from geothermal sources.Environ. Health Perspect. 12 1–8

    Google Scholar 

  • Saknyn A V and Shabynina N K 1970 Some statistical data on carcinogenous hazards for workers engaged in the production of nickel from oxidized ores;Gig. Tr. Prof. Zabol. 14 10–13

    CAS  PubMed  Google Scholar 

  • Saknyn A V and Shabynina N K 1973 Epidemiology of malignant neoplasms in nickel plants;Gig. Tr. Prof. Zabol. 17 25–28

    CAS  PubMed  Google Scholar 

  • Schade S G, Felsher B F, Bernier G M and Conrad M E 1970 Interrelationship of cobalt and iron absorption;J. Lab. Clin. Med. 75 435–441

    CAS  PubMed  Google Scholar 

  • Schrauzer G M and Ishmael D 1974 Effects of seelnium and of arsenic on the genesis of spontaneous mammary tumours in inbred C3H mice;Am. Clin. Lab. Sci. 4 441–447

    CAS  Google Scholar 

  • Schroeder H A 1966 Municipal drinking water and cardiovascular death rates;J.A.M.A. 195 81

    CAS  PubMed  Google Scholar 

  • Schroeder H A, Frost D V and Balassa J J 1970a Essential trace metals in man; selenium;J. Chron. Dis. 23 227–243

    CAS  PubMed  Google Scholar 

  • Schroeder H A, Balassa J J and Tipton I H 1970b Essential trace metals in man: Molybdenum;J. Chron. Dis. 23 481–499

    Google Scholar 

  • Schroeder H A and Mitchner M 1971 Toxic effects of trace elements on the reproduction of mice and rats;Arch. Environ. Health 23 102–106

    CAS  PubMed  Google Scholar 

  • Shamberger R J 1970 Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis;J. Nat. Cancer Inst. 44 931–936

    CAS  PubMed  Google Scholar 

  • Shamberger R J 1974 Antioxidants and cancer. III. Selenium and other antioxidants decrease carcinogen-induced chromosome linkage, inTrace Element Metabolism in Animals III eds W G Hoekstra, J W Suttie, H E Ganther and W Mertz (Baltimore: University Park Press) pp 593–597

    Google Scholar 

  • Shamberger R J and Willis C E 1971 Selenium distribution and human cancer mortality;Crit. Rev. Clin. Lab. Sci. 2 211–221

    CAS  Google Scholar 

  • Shapiro J R 1972 Selenium and carcinogeneis;Ann. N.Y. Acad. Sci. 192 215–219

    CAS  PubMed  Google Scholar 

  • Sharma A K and Sharma A 1960 Spontaneous and chemically induced chromosome breaks;Int. Rev. Cytol. 10 101–136

    CAS  Google Scholar 

  • Sibatani A 1959In vitro incorporation of32P into nucleic acids of lymphatic cell;Exp. Cell Res. 17 131

    CAS  PubMed  Google Scholar 

  • Sjoberg S G 1951 Health hazards in the production and handling of vanadium pentoxide;Arch. Ind. Health 3 631

    CAS  Google Scholar 

  • Sorewark R 1967 Vanadium in some biological specimens;J. Nutr. 92 183

    Google Scholar 

  • Stokinger H E 1967Industrial hygiene and toxicology 2nd ed; (ed.) F A Patty (New York: Interscience)2 1171–1182

    Google Scholar 

  • Stocks P 1960 On the relation between atmospheric pollution in urban and rural localities and mortality from cancer, bronchitis and pneumonia with particular reference to 3, 4-benzo-pyrene, beryllium, molybdenum, vanadium and arsenic;Br. J. Cancer 14 397–410

    CAS  Google Scholar 

  • Straus W 1956 Concentration of acid phosphatase, ribonuclease, desoxyribonuclease,β-glucuronidase, and cathepsin in “droplets” isolated from the kidney cells of normal rats;J. Biophys. Biochem. Cytol. 2 513–521

    Article  CAS  PubMed  Google Scholar 

  • Sunderman F W Jr 1967 Nickel carbonyl inhibition of cortisone induction of hepatic tryptophan pyrrolase;Cancer Res. 27 1595–1599

    CAS  PubMed  Google Scholar 

  • Sunderman F W Jr 1968 Nickel carbonyl inhibition of phenobarbital induction of hepatic cytochrome-p-450;Cancer Res. 28 465–470

    CAS  PubMed  Google Scholar 

  • Sunderman F W Jr 1970 Effect of nickel carbonyl upon incorporation of14C-leucine into hepatic microsomal proteins;Res. Commun. Chem. Path. Pharmacol. 1 161–168

    CAS  Google Scholar 

  • Sunderman F W Jr 1971 Metal carcinogenesis in experimental animals;Food Cosmet. Toxicol. 9 105–120

    CAS  PubMed  Google Scholar 

  • Sunderman F W Jr 1973 The current status of nickel carcinogenesis;Ann. Clin. Lab. Sci. 3 156–180

    PubMed  Google Scholar 

  • Sunderman F W Jr and Selin C E 1968 The metabolism of nickel carbonyl;Toxicol. Appl. Pharmacol. 12 207–218

    CAS  PubMed  Google Scholar 

  • Sunderman F W Jr and Leibman K C 1970 Nickel carbonyl inhibition of induction of aminopyrine demethylase activity in liver and lung;Cancer Res. 30 1645–1650

    CAS  PubMed  Google Scholar 

  • Sunderman F W Jr and Mastromatteo E 1975Nickel carcinogenesis: In nickel, eds F W Sunderman F Coulston, G L Eichorn, J A Fellows, E Mastromatteo, H T Reno and M H Samitz (Washington: National Academy of Sciences)

    Google Scholar 

  • Swanson S A V, Freeman M A R and Heath J C 1973 Laboratory tests on total joint replacement protheses;J. Bone Jt. Surg. B55 759–773

    Google Scholar 

  • Swierenga S H H 1970The role of nickel in the induction of muscle tumors, doctoral dissertation (Ontario: University of Guelph) pp 1–61

    Google Scholar 

  • Swierenga S H H and Basrur P K 1968 Effect of nickel on cultured rat embryo muscle cells;Lab. Invest. 19 663–674

    CAS  PubMed  Google Scholar 

  • Synder F and Kyker G C 1964 Triglyceride accumulation and release in the rare earth fatty liver;Proc. Soc. Exp. Biol. Med. 116 890

    Google Scholar 

  • Synder F, Cress E A and Kyker G C 1959 Lipid responses to intravenous rare earths in rats;J. Lipid Res. 1 125–131

    Google Scholar 

  • Tephly T R and Hibbeln P 1971 The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450;Biochem. Biophys. Res. Commun. 42 489–495

    Google Scholar 

  • Thomas J W and Moss S 1951 The effect of orally administered molybdenum on growth, spermatogenesis and testis histology of young dairy bulls;J. Dairy Sci. 34 929–936

    Article  CAS  Google Scholar 

  • Tokanehara S, Akao S and Tagaya S 1956 Blood findings in infantile arsenic toxicosis caused by powdered milk;Shonika Rinsho 9 1078–1084

    Google Scholar 

  • Touraine R and Rambaud G 1968 Les cancer bronchique primitifs a localization double unilaterale;J. Franc. Med. Chirug. 22 757–967

    CAS  Google Scholar 

  • Tregan L and Furst A 1970 Inhibition of interferon synthesis in mammalian cell cultures after nickel treatment;Res. Commun. Chem. Pharmacol. 1 395–402

    Google Scholar 

  • Tscherkes L A, Aptekar S G and Volgarev M N 1961 Hepatic tumors induced by selenium;Byull. Eksp. Biol. Med. 53 78–82

    Google Scholar 

  • Tscherkes L A, Volgarev M N and Aptekar S G 1963 Selenium caused tumors;Acta Un. Int. Cancer 19 632–633

    CAS  Google Scholar 

  • Tseng W P, Chu A M, How S W, Fong J M, Lin C S and Yeh S 1968 Prevalence of skin cancer in an epidemic area of chronic arsenicism in Taiwan;J. Nat. Cancer Inst. 40 453–463

    CAS  PubMed  Google Scholar 

  • Tsuda S 1974 Effects of 2, 4-dinitrophenol, sodium arsenate and oligomycin on mitosis of mouse L cells growing in monolayer culture. Tokushina;J. Exp. Med. 21 49–59

    CAS  Google Scholar 

  • Underwood E J 1961Trace elements in human and animal nutrition, 3rd edition (New York: Academic Press)

    Google Scholar 

  • Valberg L S 1971 Cobalt absorption, inIntestinal absorption of metal ions, trace elements and radionucleides eds S C Skoryna and D Waldron-Edward (Oxford: Pergamon Press) pp 257–263

    Google Scholar 

  • Van Campenhout E 1955 The cytotoxic effect of cobalt salts on the alpha cells of the islands of langerhans;J. Exp. Zool. 129 535–560

    Google Scholar 

  • Venugopal B and Luckey T D 1978Metal toxicity in mammals, (New York: Plenum press)

    Google Scholar 

  • Volgarev M N and Tscherkes L A 1967 Further studies in tissue changes associated with sodium selenate, in Selenium in biomedicine (Connecticut: AVI Publishing Co.) pp 179–184

    Google Scholar 

  • Virtue J A 1972 The relationship between the refining of nickel and cancer of the nasal cavity;Can. J. Otolaryngol. 1 37–42

    Google Scholar 

  • Wagner S L and Weswig P 1974 Arsenic in blood and urine of forest workers;Arch. Environ. Health Perspect. 12 9–18

    Google Scholar 

  • Walker G W R and Ting K P 1967 Effects of selenium on recombination in barley;Can. J. Genet. Cytol. 9 314–320

    CAS  PubMed  Google Scholar 

  • Waters M D, Gardner D E and Coffin D L 1974 Cytotoxic effects of vanadium on rabbit alveolar macrophagein vitro.Toxicol Appl. Pharmacol. 28 253

    CAS  PubMed  Google Scholar 

  • Webb M 1962 The biological action of cobalt and other metals. III. Chelation of cations by dihydrolipoic acid;Biochem. Biophys. Acta 65 47–65

    CAS  PubMed  Google Scholar 

  • Webb M and Weinzieri S M 1972 Uptake of63Ni2+ from its complexes with proteins and other ligands by mouse dermal fibroblastsin vitro.Br. J. Cancer 26 292–298

    CAS  PubMed  Google Scholar 

  • Webber J 1972 Effects of toxic metals in sewage on crops;Water Pollut. Control. 71 404

    CAS  Google Scholar 

  • Weinstein B, Greenberger D, Sugimura S and Fink L M Chemical carcinogenesis and RNA;Cancer Res. 31 651–655

  • Wiberg G S 1968 The effect of cobalt ions on energy metabolism in the rat;Can. J. Biochem. 46 549

    CAS  PubMed  Google Scholar 

  • Witschi H 1972 A comparative study ofin vivo RNA and protein synthesis in rat liver and lung;Cancer Res. 32 1686–1694

    CAS  PubMed  Google Scholar 

  • Wright W R 1968Metabolic interrelationship between vanadium and chromium, Ph.D. Thesis, North Carolina State University, Raleigh

    Google Scholar 

  • Yamashita N, Doi M, Nishio M, Hojo H and Tanaka M 1972 Current state of Kyoto children poisoned by arsenic tainted worinaga dry milk;Nippon Eiseigaku Zasshi 27 364–399

    CAS  PubMed  Google Scholar 

  • Yeh S 1973 Skin cancer in chronic arsenicalism;Human Pathol. 4 469–485

    CAS  Google Scholar 

  • Zachariae H 1972 Arsenik og cancerrisko;Ugeskr. Laeg. 134 2720–2721

    CAS  PubMed  Google Scholar 

  • Znamenskii W V 1963 Occupational bronchogenic pulmonary cancers in workers extracting, isolating and reprocessing nickel ore;Vor. Onkol. 9 130–131

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Bacteriology, Institute for Post-graduate Medical Education and Research, 700 020, Calcutta, India

    Ashok Kumar Giri, Ratna Banerjee, Geeta Talukder & Archana Sharma

  2. Human Genetics Laboratory, Department of Botany, University of Calcutta, 35, Ballygunj Circular Road, 700 019, Calcutta, India

    Ratna Banerjee & Archana Sharma

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  1. Ashok Kumar Giri
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Giri, A.K., Banerjee, R., Talukder, G. et al. Mutagenic effects of certain common metal toxicants on mammalian systems. Proc Ani Sci 89, 311–331 (1980). https://doi.org/10.1007/BF03179185

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