Skip to main content
Log in

A spreadsheet to determine the volume ratio for target and breast in partial breast irradiation*

  • Technical Paper
  • Published:
Australasian Physics & Engineering Sciences in Medicine Aims and scope Submit manuscript

Abstract

The technical feasibility of Partial Breast Irradiation (PBI) using external beam radiotherapy depends on the ratio between the evaluation planning target volume (PTV_eval) and the whole breast volume (“PBI volume ratio” = PVR). We aimed to develop a simple method to determine PVR using measurements performed at the time of the planning CT scan. A PVR calculation tool was developed using a Microsoft Excel spreadsheet to determine the PTV from three orthogonal dimensions of the seroma cavity and a given margin on the CT scans. The breast volume is estimated from the separation and breast height in five equally spaced CT slices. The PTV_eval and whole breast volume were determined for 29 patients from two centres using the spreadsheet calculation tool and compared to volumes delineated on computerised treatment planning systems. Both the PTV_eval and whole breast volumes were underestimated by approximately 25% using the spreadsheet. The resulting PVRs were 1.05±0.35 (mean ±1SD) times larger than the ones determined from planning. Estimations of the PVR using the calculation tool were achievable in around 5 minutes at the time of CT scanning and allow a prompt decision on the suitability of the patients for PBI.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Sarin, R.partial-breast treatment for early breast cancer: emergence of a new paradigm. Nat. Clin. Pract. Oncol. 2, 40–47, 2005.

    Article  PubMed  Google Scholar 

  2. Polgar, C., Major, T., Fodor, J., et al.High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast-conserving surgery: seven-year results of a comparative study, Int. J. Radiat. Oncol. Biol. Phys. 60, 1173–1181, 2004.

    PubMed  Google Scholar 

  3. Bensaleh, S., Bezak, E., Borg, M.Review of MammoSite brachytherapy: Advantages, disadvantages and clinical outcomes, Acta Oncol. 2008, 1–8.

  4. Vaidya, J.S., Baum, M., Tobias, J.S., et al.Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost, Int. J. Radiat. Oncol. Biol. Phys. 66, 1335–1338, 2006.

    PubMed  Google Scholar 

  5. Moon, S.H., Shin, K.H., Kim, T.H., et al.Dosimetric comparison of four different external beam partial breast irradiation techniques: Three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, helical tomotherapy, and proton beam therapy. Radiother. Oncol. 90, 66–73, 2009.

    Article  PubMed  Google Scholar 

  6. Sanders, M.E., Scroggins, T., Ampil, F.L., et al.Accelerated partial breast irradiation in early-stage breast cancer, J. Clin. Oncol. 25, 996–1002, 2007.

    Article  PubMed  Google Scholar 

  7. Vicini, F., Winter, K., Straube, W., et al.A phase I/II trial to evaluate three-dimensional conformal radiation therapy confined to the region of the lumpectomy cavity for Stage I/II breast carcinoma: initial report of feasibility and reproducibility of Radiation Therapy Oncology Group (RTOG) Study 0319, Int. J. Radiat. Oncol. Biol. Phys. 63, 1531–1537, 2005.

    Article  PubMed  Google Scholar 

  8. Sher, D.J., Wittenberg, E., Taghian, A.G., et al.Partial breast irradiation versus whole breast radiotherapy for early-stage breast cancer: a decision analysis, Int. J. Radiat. Oncol. Biol. Phys. 70, 469–476, 2008.

    PubMed  Google Scholar 

  9. Vicini, F.A., Remouchamps, V., Wallace, M., et al.Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy, Int. J. Radiat. Oncol. Biol. Phys. 57, 1247–1253, 2003.

    PubMed  Google Scholar 

  10. Oliver, M., Chen, J., Wong, E., et al.A treatment planning study comparing whole breast radiation therapy against conformal, IMRT and tomotherapy for accelerated partial breast irradiation, Radiother. Oncol. 82, 317–323, 2007.

    Article  PubMed  Google Scholar 

  11. Sher, D.J., Wittenberg, E., Suh, W.W., et al. Partial-Breast Irradiation Versus Whole-Breast Irradiation for Early-Stage Breast Cancer: A Cost-Effectiveness Analysis, Int. J. Radiat. Oncol. Biol. Phys. e-pub 10/2008.

  12. Budrukkar, A.N., Sarin, R., Shrivastava, S.K., et al.Cosmesis, late sequelae and local control after breast-conserving therapy: influence of type of tumour bed boost and adjuvant chemotherapy, Clin. Oncol. (R. Coll. Radiol.) 19, 596–603, 2007.

    CAS  Google Scholar 

  13. Sauer, R., Sautter-Bihl, M.L., Budach, W., et al.Accelerated partial breast irradiation: consensus statement of 3 German Oncology societies, Cancer 110, 1187–1194, 2007.

    Article  PubMed  Google Scholar 

  14. Wong, E.K., Truong, P.T., Kader, H.A., et al.Consistency in seroma contouring for partial breast radiotherapy: impact of guidelines, Int. J. Radiat. Oncol. Biol. Phys. 66, 372–376, 2006.

    PubMed  Google Scholar 

  15. Petersen, R.P., Truong, P.T., Kader, H.A., et al.Target volume delineation for partial breast radiotherapy planning: clinical characteristics associated with low interobserver concordance, Int. J. Radiat. Oncol. Biol. Phys. 69, 41–48, 2007.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Kron.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kron, T., Willis, D., Miller, J. et al. A spreadsheet to determine the volume ratio for target and breast in partial breast irradiation*. Australas. Phys. Eng. Sci. Med. 32, 98–104 (2009). https://doi.org/10.1007/BF03178635

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03178635

Key words

Navigation