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The clinical application of PET/CT: a contemporary review

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Abstract

The combination of positron emission tomography (PET) scanners and x-ray computed tomography (CT) scanners into a single PET/CT scanner has resulted in significant improvements in the diagnosis and staging of disease, particularly in the field of oncology. A decade on from the publication of the details of the first PET/CT scanner, we review the technology and applications of the modality. We examine the design aspects of combining two different imaging types into a single scanner, and the artefacts produced such as attenuation correction, motion and CT truncation artefacts. The article also provides a discussion and literature review of the applications of PET/CT to date, covering detection of tumours, radiotherapy treatment planning, patient management, and applications external to the field of oncology.

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Authors and Affiliations

  1. Radiology Department, The Alfred Hospital, Prahran, Australia

    Z. Brady

  2. Applied Physics, RMIT University, Melbourne, Australia

    Z. Brady, M. L. Taylor, M. Haynes, M. Whitaker, A. Mullen & L. Clews

  3. William Buckland Radiotherapy Centre (WBRC), The Alfred Hospital, Prahran, Australia

    M. L. Taylor & M. Haynes

  4. Royal Prince Alfred Hospital, Missenden Rd, Camperdown, Australia

    M. Whitaker

  5. Peter MacCallum Cancer Centre, Australia

    A. Mullen & R. J. Hicks

  6. Calvary Mater Newcastle, Warratah, Australia

    L. Clews

  7. Joint Department of Physics, The Institute of Cancer Research, Sutton, UK

    M. Partridge

  8. School of Physical and Chemical Sciences, QUT, GPO Box 2434, 4001, Brisbane, Queensland, Australia

    J. V. Trapp

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Brady, Z., Taylor, M.L., Haynes, M. et al. The clinical application of PET/CT: a contemporary review. Australas. Phys. Eng. Sci. Med. 31, 90–109 (2008). https://doi.org/10.1007/BF03178584

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