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Proton magnetic relaxation process during the polymerization of hemoglobin S

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Abstract

The proton spin-lattice and spin-spin magnetic relaxation times are investigated at 4 MHz in samples of hemoglobin A and S with intracellular concentrations, at 36 °C, and during spontaneous deoxygenation. Magnetic relaxation behaves differently in the solutions of hemoglobin A and S. The possible causes of this behavior are discussed: changes in molecular mobility, the variations of hemoglobin magnetism, and the appearance of microinhomogeneities in the solutions of hemoglobin S at the end of the polymerization process.

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Authors and Affiliations

  1. Biophysics and Medical Physics Centre, University of Oriente, Patricio Lumumba, s/n, CP 90 500, Santiago de Cuba, Cuba

    M. Lores & C. Cabal

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  1. M. Lores
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  2. C. Cabal
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Correspondence to M. Lores.

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Lores, M., Cabal, C. Proton magnetic relaxation process during the polymerization of hemoglobin S. Appl. Magn. Reson. 28, 79–84 (2005). https://doi.org/10.1007/BF03166995

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  • DOI: https://doi.org/10.1007/BF03166995

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