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Broad-band NMR with a high spectral and spatial resolution

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Abstract

Spatially selective excitation sequence CARVE (completely arbitrary regional volume excitation) excites signal from an arbitrarily shaped profile (I. Sersa, S. Macura: Magn. Reson. Med.37, 920–931, 1997) by an interleaved sequence of precalculated small tip angle radio-frequency pulses and gradient pulses. Here we propose a spatially selective observation method based on the CARVE principles which is insensitive to the relaxation and the off-resonance effects. The method, CARVED (CARVE detection), excites spins uniformly across the sample and across the spectrum but achieves spatial selectivity by weighted coaddition of the signals after the data acquisition. CARVE-D is suitable for spatially selective high-resolution nuclear magnetic resonance spectroscopy in chemically and geometrically complex systems. The method is analyzed theoretically and demonstrated experimentally on model systems.

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References

  1. Mueller S., Aue W.P., Seelig J.: J. Magn. Reson.65, 332–338 (1985)

    ADS  Google Scholar 

  2. Aue W.P., Muller S., Cross T., Seelig J.: J. Magn. Reson.56, 350–354, (1984)

    ADS  Google Scholar 

  3. Frahm J., Haenicke W.: J. Magn. Reson.60, 320–332 (1984)

    ADS  Google Scholar 

  4. Doddrell D., Bulsing J., Galloway G., Brooks W., Field J., Irving M., Baddeley H.: J. Magn. Reson.70, 319–326 (1986)

    ADS  Google Scholar 

  5. Doddrell D.M., Brooks W.M., Bulsing J.M., Field J., Irving M.G., Baddeley H.: J. Magn. Reson.68, 367–372 (1986)

    ADS  Google Scholar 

  6. Connelly A., Lohman J.: J. Magn. Reson.66, 283–294 (1986)

    ADS  Google Scholar 

  7. Connelly A., Counsell C., Lohman J.: J. Magn. Reson.78, 519–525 (1988)

    ADS  Google Scholar 

  8. Frahm J., Hänicke W.: J. Magn. Reson.60, 320 (1986)

    ADS  Google Scholar 

  9. Pauly J., Nishimura D., Macovski A.: J. Magn. Reson.81, 43–56 (1989)

    ADS  Google Scholar 

  10. Pauly J., Nishimura D., Macovski A.: J. Magn. Reson.82, 571–587 (1989)

    ADS  Google Scholar 

  11. Meyer C.H., Pauly J.M., Macovski A., Nishimura D.G.: Magn. Reson. Med.15, 287–304 (1990)

    Article  Google Scholar 

  12. Spielman D., Pauly J., Macovski A., Enzmann D.: Magn. Reson. Med.19, 67–84 (1991)

    Article  Google Scholar 

  13. Sersa I., Macura S.: J. Magn. Reson. B111, 186–188 (1996)

    Article  Google Scholar 

  14. Sersa I., Macura S.: Magn. Reson. Med.37, 920–931 (1997)

    Article  Google Scholar 

  15. Sersa I., Macura S.: J. Imag. Sci. Technol.10, 225–241 (1999)

    Google Scholar 

  16. Morrell G., Macovski A.: Magn. Reson. Med.37, 378–386 (1997)

    Article  Google Scholar 

  17. Serša I., Macura S.: J. Magn. Reson.135, 466–477 (1998)

    Article  ADS  Google Scholar 

  18. Morris G.A., Freeman R.: J. Magn. Reson.29, 433–462 (1978)

    ADS  Google Scholar 

  19. Mareci T.H.: J. Magn. Reson.57, 157–163 (1984)

    ADS  Google Scholar 

  20. Brooker H.R., Mareci T.H., Mao J.: Magn. Reson. Med.5, 417–433 (1987)

    Article  Google Scholar 

  21. Hu X., Levin D.N., Lauterbur P.C., Spraggins T.: Magn. Reson. Med.8, 314–322 (1988)

    Article  Google Scholar 

  22. Serša I., Macura S.: J. Magn. Reson.143, 208–212 (2000)

    Article  ADS  Google Scholar 

  23. Metropolis N., Rosenbluth A.W., Rosenbluth M.N., Teller A.H., Teller E.: J. Chem. Phys.21, 1087–1092 (1953)

    Article  ADS  Google Scholar 

  24. Scheffler K., Henning J.: Magn. Reson. Med.35, 569–576 (1996)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Condensed Matter Physics, Jožef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia

    I. Serša

  2. Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    S. Macura

Authors
  1. I. Serša
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  2. S. Macura
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Serša, I., Macura, S. Broad-band NMR with a high spectral and spatial resolution. Appl. Magn. Reson. 22, 277–290 (2002). https://doi.org/10.1007/BF03166110

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  • DOI: https://doi.org/10.1007/BF03166110

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