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Intense and prolonged Tl-201 accumulation in a slow growing bronchioloalveolar carcinoma

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Abstract

Thallium-201 SPECT was performed to evaluate a pulmonary lesion in a 73-year-old male which had been considered to be an inflammatory lesion for two years. The lesion has slowly increased in size on x-CT. Tl-201 was intensely taken up and retained in the lesion, suggesting a malignant lesion. Histological examination revealed that the lesion was bronchioloalveolar carcinoma. This case suggested that Tl-201 uptake of pulmonary carcinoma would not be necessarily related to cell growth rate.

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References

  1. Tonami N, Shuke N, Yokoyama K, Seki H, Takayama T, Kinuya S, et al. Thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer.J Nucl Med 30: 997–1004, 1989.

    PubMed  CAS  Google Scholar 

  2. Tonami N, Yokoyama K, Taki J, Shuke N, Kinuya S, Nakajima K, et al. Tl-201 SPECT in the detection of mediastinal lymph node metastases from lung cancer.Nucl Med Commun 12: 779–792, 1991.

    Article  PubMed  CAS  Google Scholar 

  3. Tonami N, Yokoyama K, Shuke N, Taki J, Kinuya S, Miyauchi T, et al. Evaluation of suspected malignant pulmonary lesions with Tl-201 single photon emission computed tomography.Nucl Med Commun 14: 602–610, 1993.

    Article  PubMed  CAS  Google Scholar 

  4. Tonami N, Itoh K, Nobuharu Y, Terui S, Torizuka K. Clinical usefulness of thallium-201 chloride in the diagnosis of tumor (II)—an evaluation in bone, soft tissue and mediastinal tumors.KAKU IGAKU (Jpn J Nucl Med) 31: 63–73, 1994.

    CAS  Google Scholar 

  5. Ramanna L, Waxman A, Binney G, Waxman S, Mirra J, Rosen G. Thallium-201 scintigraphy in bone sarcoma: comparison with gallium-67 and thechnetium-MDP in the evaluation of chemotherapeutic response.J Nucl Med 31: 567–572, 1990.

    PubMed  CAS  Google Scholar 

  6. Kaplan WD, Takvorisn T, Morris JH, Rumbaugh CL, Connolly BT, Atkins HL. Thallium-201 brain tumor imaging: A comparative study with pathologic correlation.J Nucl Med 28: 47–52, 1987.

    PubMed  CAS  Google Scholar 

  7. Yoshii Y, Satou M, Yamamoto T, Yamada Y, Hyodo A, Nose T, et al. The role of thallium-201 single photon emission tomography in the investigation and characteriza- tion of brain tomours in man and their response to treatment.EurJ Nucl Med 20: 39–45, 1993.

    Article  CAS  Google Scholar 

  8. Black KL, Hawkins RA, Kim KT, Becker DP, Lerner C, Marciano D. Use of thallium-201 SPECT to quantitative malignancy grade of gliomas.J Neurosurg 71: 342–346, 1989.

    Article  PubMed  CAS  Google Scholar 

  9. Oriuchi N, Tamura M, Shibazaki T, Ohye C, Watanabe N, Tateno M, et al. Clinical evaluation of thallium-201 SPECT in supratentorial gliomas: relationship to histologic grade, prognosis and proliferative activities.J Nucl Med 34: 2085- 2089, 1993.

    PubMed  CAS  Google Scholar 

  10. Ishibashi M, Taguchi A, Sugita Y, Monta S, Kawamura S, Umezaki N, et al. Thallium-201 in brain tumors: relation- ship between tumor cell activity in astrocytic tumor and proliferating cell nuclear antigen.J Nucl Med 36: 2201- 2206, 1995.

    PubMed  CAS  Google Scholar 

  11. Winchell HS. Mechanisms for localization of radiopharmaceuticals in neoplasms.Semin Nucl Med 6: 371–396, 1976.

    Article  PubMed  CAS  Google Scholar 

  12. Sehweil A, el-Sayed M, Ziada G, Al-Huda F, Mobarak L, Omar YT, et al. Thallium-201 kinetics in malignant tumors.J Nucl Med 27: 1033, 1986.

    Google Scholar 

  13. Ando A, Ando I, Katayama M, Sanada S, Hiraki T, Mori H, et al. Biodistributions of201Tl in tumor bearing animals and inflammatory lesion induced animals.Eur J Nucl Med 12: 567–572, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Sehweil AM, McKillop JH, Milroy R, Wilson R, Abdel-Dayem HM, Omar YT. Mechanism of201Tl uptake in tumors.Eur J Nucl Med 15: 376–379, 1989.

    Article  PubMed  CAS  Google Scholar 

  15. Ito Y, Muranaka A, Harada T, Matsudo A, Yokobayashi T, Terashima H. Experimental study on tumor affinity of201Tl-chloride.Eur J Nucl Med 3: 81–86, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Caulser C, Macapinlac H, Healey J, Ghavimi F, Meyers P, Wollner N, et al. The relationship between thallium uptake, blood flow, and blood pool activity in bone and soft tissue tumors.Clin Nucl Med 17: 565–572, 1992.

    Article  Google Scholar 

  17. Elligsen JD, Thompson JE, Frey HE, Kruuv J. Correlation of (Na+-K+)-ATPase activity with growth of normal and transformed cells.Exp Cell Res 87: 233–240, 1974.

    Article  PubMed  CAS  Google Scholar 

  18. Hoh CK, Khanna S, Harris GC, Chen TT, Black KL, Becker DP, et al. Evaluation of brain tumor recurrence with Tl-201 SPECT studies: Correlation with FDG PET and histological result.J Nucl Med 33: 867, 1992.

    Google Scholar 

  19. Schwartz M. A biomathematical approach to clinical tumor growth.Cancer 14: 1272–1294, 1961.

    Article  PubMed  CAS  Google Scholar 

  20. Heikkila L, Mattila P, Harjula A, Sumalainen PJ, Mattila S. Tumor growth rate and its relationship to prognosis in bronchiolo-alveolar and pulmonary adenocarcinoma.Ann Chir Gynaecol 74: 210–214, 1985.

    PubMed  CAS  Google Scholar 

  21. Garland LH, Coulson W, Wollin E. The rate of growth and apparent duration of untreated primary bronchial carcinoma.Cancer 16: 694–707, 1963.

    Article  PubMed  CAS  Google Scholar 

  22. Spratt JS, Spjut HJ, Roper CL. The frequency distribution of the rates of growth and the estimated duration of primary pulmonary carcinomas.Cancer 16: 687–693, 1963.

    Article  PubMed  Google Scholar 

  23. Kishida T. Mechanisms of thallium-201 accumulation to thyroid gland—clinical usefulness of dynamic study in thallium-201 chloride scintigraphy for differential diagno- sis of thyroid nodules.KAKU JGAKU (Jpn J Nucl Med) 24: 991–1004, 1987.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, 920, Ishikawa, Japan

    Seigo Kinuya, Takatoshi Michigishi & Norihisa Tonami

  2. Department of Radiology, Saiseikai Kanazawa Hospital, Japan

    Shiro Takahashi

  3. Department of Internal Medicine, Saiseikai Kanazawa Hospital, Japan

    Motoyasu Saito & Yohei Tofuku

Authors
  1. Seigo Kinuya
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  2. Shiro Takahashi
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  3. Motoyasu Saito
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  4. Yohei Tofuku
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  5. Takatoshi Michigishi
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  6. Norihisa Tonami
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Kinuya, S., Takahashi, S., Saito, M. et al. Intense and prolonged Tl-201 accumulation in a slow growing bronchioloalveolar carcinoma. Ann Nucl Med 10, 261–264 (1996). https://doi.org/10.1007/BF03165403

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  • DOI: https://doi.org/10.1007/BF03165403

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