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Differences between99mTc-DTPA and99mTc-MAG3 captopril renographies in renovascular hypertension

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Abstract

Captopril renography (CRS) with99mTc-DTPA and99mTc-MAG3 was performed on a 21-year-old woman with renovascular hypertension due to right renal artery stenosis caused by fibromuscular dysplasia. In the affected kidney, the renogram pattern was substantially changed with99mTc-DTPA and99mTc-MAG3 following the administration of captopril, and the quantitated renal uptake indicating individual renal function was significantly decreased in99mTc-DTPA and slightly decreased in99mTc-MAG3. In the contralateral normal kidney, the renogram showed some minor changes with both radioagents, while the quantitated renal uptake was significantly decreased with99mTc-DTPA and substantially increased with99mTc-MAG3. The combined use of physiologically different renal agents99mTc-DTPA and99mTc-MAG3 is helpful in investigating hemodynamic and functional changes in the stenosed kidney as well as the normal kidney in RVH.

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References

  1. Sfukianakis GN, Jaffe DJ, Bourgoignie JJ, et al. Single dose captopril renography in diagnosis of renovascular hypertension.J Nucl Med 28: 1383–1392, 1987.

    Google Scholar 

  2. Mann SJ, Pickering TG, Sos TA, et al. Captopril renography in the diagnosis of renal artery stenosis: accuracy and limitations.Am J Med 90: 30–40, 1991.

    Article  PubMed  CAS  Google Scholar 

  3. Nally JV Jr, Black HR. State-of-the-art review: captopril renography-pathopysiological considerations and clinical observations.Semin Nucl Med 22: 85–97, 1992.

    Article  PubMed  Google Scholar 

  4. Fommei E, and the European Multicentre Study Group. Captopril radionuclide test in renovascular hypertension: a European multicentre study.Eur J Nucl Med 20: 617–623, 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Elliot WJ, Martin WB, Murphy MB. Comparison of two noninvasive screening tests for renovascular hypertension.Arch Inter Med 153: 755–764, 1993.

    Article  Google Scholar 

  6. Meier GH, Sumpio B, Serato JF, Black HR, Gusberg RJ. Captopril renal scintigraphy: a new standard for predicting outcome after renal revascularization.J Vasc Surg 17: 280–287, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Shamlou KK, Drane WE, Hawkins IF, Fennell RS III. Captopril renography and the hypertensive renal transplantation patient: a predictive test of therapeutic outcome.Radiology 190: 153–159, 1994.

    PubMed  CAS  Google Scholar 

  8. Dondi M, Monetti N, Fanti S, Marchetta F, Cordelli C, Zagni P, et al. Use of technetium-99m-MAG3 for renal scintigraphy after angiotensin-converting enzyme inhibition.J Nucl Med 32: 424–428, 1991.

    PubMed  CAS  Google Scholar 

  9. Kahn D, Ben-Haim S, Bushnell DL, Madsen MT, Kirchner PT. Captopril-enhanced99mTcm-MAG3 renal scintigraphy in subjects with suspected renovascular hypertension.Nucl Med Comm 15: 515–528, 1994.

    Article  CAS  Google Scholar 

  10. Itoh K, Tsukamoto E, Nagao K, Nakada K, Kanegae K, Furudate M. Captopril renoscintigraphy with Tc-99m DTPA in patients with suspected renovascular hypertension: prospective and retrospective evaluation.Clin Nucl Med 18: 463–471, 1993.

    Article  PubMed  CAS  Google Scholar 

  11. Blaufox MD. Captopril renography, considerations in the selection of radiopharmaceuticals, provocative agents, and hypertensive subjects.Am J Hypertens 4: 675S-677S, 1991.

    PubMed  CAS  Google Scholar 

  12. Taylor A Jr, Martin LG. The utility of99mTc-mercaptoacetyltriglycine in captopril renography.Am J Hypertens 4: 731S-736S, 1991.

    PubMed  Google Scholar 

  13. Gates GF. Glomerular filtration rate: Estimation from fractional renal accumulation of99mTc-DTPA (stannous).Am J Roentgenol 138: 565–570, 1982.

    CAS  Google Scholar 

  14. Itoh K, Tsukamoto E, Kakizaki H, Nonomura K, Furudate M. Comparative study of renal scintigraphy with99mTcm- mercaptoacetyl-triglycine and123I-orthoiodohippurate.Nucl Med Comm 14: 644–652, 1993.

    Article  CAS  Google Scholar 

  15. Itoh K, Kato C, Shiga T. Expressing kidney uptake during99mTcm-MAG3 renography in terms of administered activity.Nucl Med Comm 16: 504–508, 1995.

    Article  CAS  Google Scholar 

  16. Pickering TG. Renovascular hypertension: etiology and pathophysiology.Semin Nucl Med 19: 79–88, 1989.

    Article  PubMed  CAS  Google Scholar 

  17. Lee H-B, Blaufox MD. Technetium-99m MAG3 clearances after captopril in experimental renovascular hypertension.J Nucl Med 30: 666–671, 1989.

    PubMed  CAS  Google Scholar 

  18. Miyamori I, Yasuhara S, Takedo Y, et al. Effects of converting enzyme inhibition on split renal function in renovascular hypertension.Hypertension 9: 415–421, 1986.

    Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan

    Kazuo Itoh, Chietsugu Kato & Takashi Mochizuki

  2. Department of Cardiovascular Internal Medicine, Hokkaido University School of Medicine, Japan

    Yutaka Matsui & Akira Kitabatake

Authors
  1. Kazuo Itoh
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  2. Yutaka Matsui
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  3. Chietsugu Kato
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  4. Takashi Mochizuki
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  5. Akira Kitabatake
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Itoh, K., Matsui, Y., Kato, C. et al. Differences between99mTc-DTPA and99mTc-MAG3 captopril renographies in renovascular hypertension. Ann Nucl Med 10, 251–255 (1996). https://doi.org/10.1007/BF03165401

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  • DOI: https://doi.org/10.1007/BF03165401

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