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Simplified quantification of regional cerebral blood flow with99mTc-ECD SPECT and continuous arterial blood sampling

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Abstract

The goal of this study was to develop a simple method for quantification of regional cerebral blood flow (rCBF) with99mTc-ethyl cysteinate dinier (ECD) SPECT. Following an intravenous constant infusion of ECD for one minute, serial dynamic SPECT imaging was performed for 40 minutes in 6 healthy male volunteers with intermittent arterial blood sampling. PET scan with15O-water was performed on the same day before the SPECT study for measurement of rCBF. Arterial blood data demonstrated rapid conversion of ECD to the hydrophilic metabolites, and most of the arterial input to the brain was completed within 5 minutes after the injection. Brain activity reached a peak value soon after the cessation of infusion, and was stable thereafter with very little washout. Net extraction of ECD in the brain calculated by arterial input of ECD and rCBF demonstrated a rapid decrease within a few minutes, reaching 42.7% at 5 minutes. The simulation study suggested that the arterial blood activity obtained by continuous drawing for 5 minutes and a single SPECT scan would provide a reasonable estimate of rCBF under the assumption of constant net extraction in the brain.

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Authors and Affiliations

  1. Biomedical Imaging Research Center, Fukui Medical School, 23 Shimoaizuki, Matsuoka, 910-11, Fukui, Japan

    Yoshiharu Yonekura, Norihiro Sadato & Tatsuro Tsuchida

  2. Department of Nuclear Medicine, Kyoto University School of Medicine, Japan

    Yoshiharu Yonekura, Koichi Ishizu, Hidehiko Okazawa, Fumiko Tanaka, Naoya Hattori, Sadahiko Nishizawa, Nagara Tamaki & Junji Konishi

  3. Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan

    Takashi Nagamine & Hiroshi Shibasaki

Authors
  1. Yoshiharu Yonekura
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  2. Koichi Ishizu
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  3. Hidehiko Okazawa
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  4. Fumiko Tanaka
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  5. Naoya Hattori
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  6. Norihiro Sadato
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  7. Tatsuro Tsuchida
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  8. Sadahiko Nishizawa
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  9. Nagara Tamaki
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  10. Takashi Nagamine
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  11. Junji Konishi
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  12. Hiroshi Shibasaki
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Yonekura, Y., Ishizu, K., Okazawa, H. et al. Simplified quantification of regional cerebral blood flow with99mTc-ECD SPECT and continuous arterial blood sampling. Ann Nucl Med 10, 177–183 (1996). https://doi.org/10.1007/BF03165390

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  • DOI: https://doi.org/10.1007/BF03165390

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