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Evaluation of left ventricular wall motion and function in patients with previous myocardial infarction by three-dimensional99mTc-HSAD multigated cardiac pool imaging

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Abstract

To evaluate left ventricular (LV) wall motion stereoscopically from all directions and to calculate the LV volume by three-dimensional (3D) imaging,99mTc-DTPA human serum albumin-multigated cardiac pool-single photon emission computed tomography (99mTc-MUGA-SPECT) was performed. A new data processing program was developed with the Application Visualization System-Medical Viewer (AVS-MV) based on images obtained from99mTc-MUGA-SPECT. In patients with previous myocardial infarction, LV function and LV wall motion were evaluated by 3D-99mTc-MUGA imaging. The LV end-diastolic volume (LVEDV) and end-systolic volume (LVESV) were obtained from 3D-99mTc-MUGA images by the surface rendering method, and the left ventricular ejection fraction (LVEF) was calculated at thresholds of 35% (T1), 40% (T2), 45% (T3), and 50% (T4). There was a strong correlation between the LV volume calculated by 3D-99mTc-MUGA imaging at a threshold of 40% and that determined by contrast left ventriculography (LVEDV: 194.7 ± 36.0ml vs. 198.7 ± 39.1ml, r = 0.791, p < 0.001; LVESV: 91.6 ± 44.5ml vs. 93.3 ± 41.3ml, r = 0.953, p < 0.001), respectively. When compared with the LVEF data obtained by left ventriculography, significant correlations were found for 3D images reconstructed at each threshold (T1: r = 0.966; T2: r = 0.962; T3: r = 0.958; and T4: r = 0.955). In addition, when LV wall motion obtained by 3D-99mTc-MUGA imaging (LAT and LAO views) was compared with the results obtained by left ventriculography (RAO and LAO views), there was good agreement.

3D-99mTc-MUGA imaging was superior in allowing evaluation of LV wall motion in all directions and in assessment of LV function, since data acquisition and image reconstruction could be done within a short time with the three-detector imaging system and AVS-MV. This method appears to be very useful for the observation of both LV wall motion and LV function in patients with ischemic heart disease, because it is a noninvasive examination.

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Authors and Affiliations

  1. First Department of Internal Medicine, Ohmori Hospital, Toho University, School of Medicine, 6-11-1 Ohmori-Nishi, Ohta-ku, 143, Tokyo, Japan

    Junichi Yamazaki, Katsutoshi Naitou, Shuichi Ishida, Nariaki Uno, Kenichiro Saisho, Takehiko Munakata & Takeshi Morishita

  2. Radioisotope Inspection Laboratory, Ohmori Hospital, Toho University School of Medicine, Japan

    Masaaki Takano

  3. Cardiovascular Diagnostic Laboratory, Ohmori Hospital, Toho University School of Medicine, Japan

    Yoshimasa Yabe

Authors
  1. Junichi Yamazaki
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  2. Katsutoshi Naitou
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  3. Shuichi Ishida
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  4. Nariaki Uno
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  5. Kenichiro Saisho
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  6. Takehiko Munakata
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  7. Takeshi Morishita
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  8. Masaaki Takano
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  9. Yoshimasa Yabe
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Yamazaki, J., Naitou, K., Ishida, S. et al. Evaluation of left ventricular wall motion and function in patients with previous myocardial infarction by three-dimensional99mTc-HSAD multigated cardiac pool imaging. Ann Nucl Med 11, 129–138 (1997). https://doi.org/10.1007/BF03164821

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  • DOI: https://doi.org/10.1007/BF03164821

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