Abstract
In order to estimate the production of reticulocytes, which have a larger number of transferrin receptors than erythrocytes, we used67Ga which is exclusively bound to transferrin in the blood. The pattern of uptake of67Ga by reticulocytes was quite similar to the time course of transglutaminase activity which might be involved in receptor-mediated endocytosis. The preinjection of Fe3+ decreased the uptake of67Ga by reticulocytes. These results suggested that67Ga in a transferrin-bound form was taken up by reticulocytes via receptor-mediated endocytosis. It was showed that the application of67Ga is very easy and useful for the estimation of reticulocyte production.
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Ohkubo, Y., Takasu, S., Itakura, M. et al. Application of67Ga for the estimation of reticulocyte production. Ann Nucl Med 6, 59–62 (1992). https://doi.org/10.1007/BF03164643
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DOI: https://doi.org/10.1007/BF03164643