Abstract
Encouraged by reports of radioimmunoimaging of colorectal carcinomas1−3 and by examining an immunohistochemical report on resected pancreas cancer tissues4, we studied the diagnostic potential of radioimmunoimaging with the radioiodinelabeled monoclonal antibody to the surface antigen of a pancreas cancer cell line. A monoclonal antibody (MoAb; HC-1) to a human pancreas cancer cell line (HGC25)5 was labeled with radioiodine and injected into athymic nude mice implanted with human pancreas cancer cells. Antibody HC-1 was cleared from the circulation and accumulated significantly in the implanted tumor sites.
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Tsuda, T., Koshiba, H., Usui, T. et al. Radioimmunoscintigraphy of human pancreatic carcinoma xenografts in nude mice with131I-labeled monoclonal antibody. Ann Nucl Med 4, 71–74 (1990). https://doi.org/10.1007/BF03164599
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DOI: https://doi.org/10.1007/BF03164599