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Recurrent malignant glioma: detection with131I labeled monoclonal antibody G-22, positron emission tomography and magnetic resonance imaging

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Abstract

A 45-year-old man with suspected recurrent malignant glioma was evaluated by magnetic resonance imaging (MRI), positron emission tomography (PET) and131I labeled monoclonal antibody G-22 (G-22) scan. Following Gadolinium-DTPA, a Tl-weighted spin echo image (TR 500 msec, TE 20 msec) demonstrated a large mass with an irregular margin in the left temporo-parietal area. An18F labeled fluorodeoxyglucose PET study demonstrated marked accumulations in the left temporo-parietal area. Serial131I-G-22 scintigraphy was obtained for a week after the injection. The uptake was most increased on the 2nd day after the injection.131I G-22 was specific for tumor-associated antigens.

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References

  1. Tyler JL, Diksic M, Villemure JG, etal: Metabolic and hemodynamic evaluation of gliomas using positron emission tomography.J Nucl Med 28: 1123–1133, 1987

    PubMed  CAS  Google Scholar 

  2. Bergh J, Nilsson S, Loljedahl C, etal: Radioimaging of human malignant glilomas using indium-labelled monoclonal antibodies.Nucl Med Comm 11: 437–444, 1990

    Article  CAS  Google Scholar 

  3. Claussen C, Lanaiado M, Kazner E, et al: Application of contrast agents in CT and MRI (NMR): their potential in imaging of brain tumors.Neuroradiol 27: 164–171, 1985

    Article  CAS  Google Scholar 

  4. Dooms GC, Hecht S, Brant-Zawadzki M, etal: Brain radiation lesions: MR imaging.Radiology 158: 149–155, 1986

    PubMed  CAS  Google Scholar 

  5. Beaney RP: Positron emission tomography in the study of human tumors.Sem Nucl Med 14: 324–341, 1984

    Article  CAS  Google Scholar 

  6. Coleman RE, Hoffman JM, Hanson MW, etal: Clinical application of PET for the evaluation of brain tumors.J Nucl Med 32: 616–622, 1991

    PubMed  CAS  Google Scholar 

  7. Di Chiro G, Hatazawa J, Katz DA, etal: Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study.Radiology 164: 521–526, 1987

    PubMed  Google Scholar 

  8. Yoshida J, Yamamoto R, Wakabayashi T, etal: Radioimmunoassay of glioma-associated antigen in cerebrospinal fluid and its usefulness for the diagnosis and monitoring of human glioma.J Neuro-Oncology 8: 23–31, 1990

    CAS  Google Scholar 

  9. Yoshida J, Mizuno M, Inoue I, etal: Radioimaging of human glioma xenografts with I labeled monoclonal antibody G-22 against glioma-associated antigen.J Neuro-Oncology 8: 221–229, 1990

    CAS  Google Scholar 

  10. Ito K, Kato T, Tadokoro M, etal: Recurrent rectal cancer and scar: differentiation with PET and MR imaging.Radiology 182: 549–552, 1992

    PubMed  CAS  Google Scholar 

  11. Dean BL, Drayer BP, Bird CR, etal: Gliomas: Classification with MR imaging.Radiology 174: 411–415, 1990

    PubMed  CAS  Google Scholar 

  12. Elster AD, Dipersio DA: Cranial postoperative site: assessment with contrast-enhanced MR imaging.Radiology 174: 93–98, 1990

    PubMed  CAS  Google Scholar 

  13. Di Chiro G: Positron emission tomography using [F-18] Fluoro-deoxyglucose in brain tumors. A powerful diagnostic and prognostic tool.Invest Radiol 22: 360–371, 1986

    Google Scholar 

  14. Di Chiro G, Oldfield E, Wright DC, etal: Cerebral necrosis after radiotherapy and/or intra-arterial chemotherapy for brain tumors: PET and neuropathologic studies.AJNR 8: 1083–1091, 1987

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Nagoya First Red Cross Hospital, Japan

    Motoo Oshima

  2. Department of Neuroswgery, Nagoya University School of Medicine, Japan

    Jun Yoshida & Toshihiko Wakabayashi

  3. Department of Radiology, Nagoya University School of Medicine, Japan

    Kengo Ito, Masanori Tadokoro, Takashi Kato & Sadayuki Sakuma

Authors
  1. Motoo Oshima
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  2. Jun Yoshida
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  3. Toshihiko Wakabayashi
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  4. Kengo Ito
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  5. Masanori Tadokoro
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  6. Takashi Kato
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  7. Sadayuki Sakuma
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Oshima, M., Yoshida, J., Wakabayashi, T. et al. Recurrent malignant glioma: detection with131I labeled monoclonal antibody G-22, positron emission tomography and magnetic resonance imaging. Ann Nucl Med 7, 119–122 (1993). https://doi.org/10.1007/BF03164577

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  • DOI: https://doi.org/10.1007/BF03164577

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