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Zum Manifestationszeitpunkt der Retinopathia praematurorum Stadium III

Time course of ROP stage III onset

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Zusammenfassung

Im Rahmen einer prospektiven Studie zur Analyse der natürlichen Verlaufsentwicklung der Retinopathia praematurorum konnte bei 22 Kindern der Manifestationszeitpunkt des Stadiums III nach vorhergehender Feststellung eines Stadiums I oder II und nachfolgend mindestens wöchentlichen Kontrollen bestimmt werden. Als Mittelwert der Stadium III-Manifestation wurden 66,5 Lebenstage bzw. 36,9 berechnete Schwangerschaftswochen ermittelt. Korrelations-, Regressions- und Faktoranalyse weisen den Risikofaktor Geburtsgewicht als relativ präzisen Prädikator für das Lebensalter der Stadium III-Manifestation aus. Durch Einführung der Risikofaktoren Schwangerschafts- und Beatmungsdauer konnte die Präzision des linearen Modells nicht wesentlich erhöht werden. Es wurde eine inverse lineare Regression zwischen Geburtsgewicht und Stadium III-Manifestation abgeleitet. Die Regressionssteilheit weist in erster Näherung eine Latenzabnahme der Stadium III-Manifestation um eine Woche bei einer Zunahme des Geburtsgewichtes von 200 Gramm aus.

Summary

In a prospective study on ROP development the age at stage III onset was determined in 22 preterms. They were enroled in the study after diagnosis of early stages (I or II). Follow-up examinations were scheduled at least weekly. The mean age of first ROP stage III observation was 66.5 days after birth or 36.9 weeks expressed as mean calculated gestational age. On the base of statistical analyses (correlation, regression, and factor) birth weight established as the most informative risk factor concerning the critical age of stage III onset. The introduction of further risk factors (gestational age and duration of O2-therapy) into the linear model was nearly without influence on the precision of the model. As a general guideline an inverse linear relation between birth weight and observed age of ROP stage III onset was established. According to this the age of stage III onset is delayed on average by one week with a decrease of 200 g in birth weight.

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Literatur

  1. Campbell K (1951) Intensive oxygen therapy as a possible cause of retrolental fibroplasia: A clinical approach. Med J Aust 2: 48–50

    PubMed  CAS  Google Scholar 

  2. Committee for the Classification of Retinopathy of Prematurity (1984) An international classification of retinopathy of prematurity. Arch Ophthalmol 102: 1130–1134

    Google Scholar 

  3. Committee for the Classification of Retinopathy of Prematurity (1987) An international classification of retinopathy of prematurity. II. The classification of retinal detachment. Arch Ophthalmol 105: 906–912

    Google Scholar 

  4. Cryotherapy for Retinopathy of Prematurity Cooperative Study Group (1988) Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Arch Ophthalmol 106: 471–479

    Google Scholar 

  5. Cryotherapy for Retinopathy of Prematurity Cooperative Study Group (1990) Multicenter trial of cryotherapy for retinopathy of prematurity. Three-month outcome. Arch Ophthalmol 108: 195–204

    Google Scholar 

  6. Cryotherapy for Retinopathy of Prematurity Cooperative Study Group (1990) Multicenter trial of cyrotherapy for retinopathy of prematurity. One-year outcome — structure and function. Arch Ophthalmol 108: 1408–1416

    Google Scholar 

  7. Dubowitz LMS, Dubowitz V, Goldberg C (1970) Clinical assessment of gestational age in the newborn infant. J Pediatr 77: 1–10

    Article  PubMed  CAS  Google Scholar 

  8. Dunn MS, Shennan AT, Hoskins EM, Lennox K, Enhorning G (1988) Two-year follow-up of infants enrolled in a randomized trial of surfactant replacement therapy for prevention of neonatal respiratory distress syndrome. Pediatrics 82: 543–547

    PubMed  CAS  Google Scholar 

  9. Hallman M, Merritt TA, Jarvenpaa AL, Boynton B, Mannino F, Gluck L, Moore T, Edwards D (1985) Exogenous human surfactant for treatment of severe respiratory distress syndrome: A randomized prospective clinical trial. J Pediatr 106: 963–969

    Article  PubMed  CAS  Google Scholar 

  10. Hindle NW (1986) Cryotherapy for retinopathy of prematurity: timing of intervention. Br J Ophthalmol 70: 269–276

    Article  PubMed  CAS  Google Scholar 

  11. Medical Research Council Conference Report (1952) Retrolental fibroplasia in the United Kingdom. Br Med J 2: 78–82

    Google Scholar 

  12. Ng YK, Fielder AR, Levene MI (1987) Retinopathy of prematurity in the United Kingdom. Eye 1: 386–390

    PubMed  Google Scholar 

  13. Kitchen WH, Ford G, Orgill A, Rickards A, Astbury J, Lissenden J, Bajuk BM, Yu V, Drew J, Campbell N (1984) Outcome in infants with birth weight 500 to 999 g: A regional study of 1979 and 1980 Births. J Pediatr 104: 921–927

    Article  PubMed  CAS  Google Scholar 

  14. Körner F, Bossi E (1984) Frühgeborenen-Retinopathie: Klassifikation und Untersuchungstechnik. In: Körner F, Bossi E (Hrsg) Die Retinopathie des Frühgeborenen. Fischer, Stuttgart, pp 41–59

    Google Scholar 

  15. Körner F, Bossi E (1984) Möglichkeit der Voraussage des retinalen Risikos Frühgeborener. In: Körner F, Bossi E (Hrsg) Die Retinopathie des Frühgeborenen. Fischer, Stuttgart, pp 65–77

    Google Scholar 

  16. Köchling R, zit.n. Metze H, Schäfer WD (1984) Epidemiologie der Frühgeborenen-Retinopathie. In: Körner F, Bossi E (Hrsg) Die Retinopathie des Frühgeborenen. Fischer, Stuttgart, pp 115–127

    Google Scholar 

  17. Patz A, Hoeck LE, DeLaCruz E (1952) Studies on the effect of high oxygen administration on retrolental fibroplasia. Am J Ophthalmol 35: 1248–1252

    PubMed  CAS  Google Scholar 

  18. Patz A (1957) The role of oxygen in retrolental fibroplasias. Pediatrics 19: 504–524

    PubMed  CAS  Google Scholar 

  19. Payne JW, Patz A (1979) Current status of retrolental fibroplasia: The retinopathy of prematurity. Ann Clin Res 11: 205–215

    PubMed  CAS  Google Scholar 

  20. Phelps DL (1981) Retinopathy of prematurity: An estimate of vision loss in the United States-1979. Pediatrics 67: 924–926

    PubMed  CAS  Google Scholar 

  21. Schmidt UM (1986) Wandel der Ursachen für Blindheit im Kindesalter. Eine Untersuchung der ophthalmologischen Diagnosen in der Bayerischen Landesschule für Blinde bezogen auf die Geburtsjahrgänge 1885–1976. Dissertation, Universität München

  22. Schulenburg WE, Prendiville A, Ohri R (1987) Natural history of retinopathy of prematurity. Br J Ophthalmol 71: 837–843

    Article  PubMed  CAS  Google Scholar 

  23. Silverman WA, Blodi FC, Locke JC, Day RL, Reese AB (1952) Incidence of retrolental fibroplasia in a New York nursery. Arch Ophthamol 48: 698–711

    CAS  Google Scholar 

  24. Silverman WA (1980) Retrolental fibroplasia: A modern parable. Grune&Stratton, New Yok, pp 4–66

    Google Scholar 

  25. Terry TL (1942) Extreme prematurity and fibroplastic outgrowth of persistent vascular sheath behind each crystalline lens. I. Prelimary report. Am J Ophthalmol 25: 203–204

    Google Scholar 

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Authors and Affiliations

  1. Augenklinik der Universität, Domagkstraße 15, D-W-4400, Münster, Bundesrepublik, Deutschland

    H. Gerding, S. Clemens, K. -H. Emmerich & H. Busse

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  1. H. Gerding
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  2. S. Clemens
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  3. K. -H. Emmerich
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  4. H. Busse
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Gerding, H., Clemens, S., Emmerich, K.H. et al. Zum Manifestationszeitpunkt der Retinopathia praematurorum Stadium III. Spektrum Augeheilkd 6, 155–159 (1992). https://doi.org/10.1007/BF03162989

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