Abstract
The aim of this research was to determine the influence of anesthesia, drugs, and neurosurgical trauma on the permeability of the blood-brain barrier (BBB) for macromolecules. Protein markers of oligodendrocytes and astroglia were used. The research methods were unique. Two groups of patients were formed: with neurosurgical brain trauma and without it. Everyone in both groups was subjected to anesthesia. The results were unexpected and did not depend on surgery:
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1.
Neurosurgical brain trauma did not change the permeability of BBB.
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2.
Anesthesia resulted in increasing permeability of BBB with peak upon 24–48 h.
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3.
High blood levels of neurospecific proteins proved protein synthesis in glial cells.
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4.
Massive transferring of brain antigens into blood did not stimulate antibody synthesis during a period of 21 d.
According to the high blood levels of neural proteins, the antigen-antibody reaction took place in blood and autoimmune complexes were eliminated before penetration into the brain. A new mechanism of brain autoimmune safety is discussed.
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Khokhlov, A.P., Fetisova, I.G., Chekhonin, V.P. et al. The changes in the permeability of the blood-brain barrier when under neurosurgical intervention. Molecular and Chemical Neuropathology 20, 197–202 (1993). https://doi.org/10.1007/BF03160073
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DOI: https://doi.org/10.1007/BF03160073