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Some evidence against the chemical theory of neuromuscular transmission

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Proceedings / Indian Academy of Sciences

Summary and Conclusions

1. Some frog’s stomach muscles and dog’s stomach muscle continuously release acetylcholine.

2. Stimulation of vagus nerve increases the release of acetylcholine.

3. After the nerve has fatigued, direct electrical stimulation releases acetylcholine; this direct stimulus is far more potent than nervous stimulation, showing that the release of acetylcholine can occur independently of nervous stimulation.

4. In dog’s stomach muscle, the release of acetylcholine continues undiminished after the nerves have fatigued. It occurs whether the nerves are further stimulated or not. This suggests that the acetylcholine released during nervous stimulation originates from the muscle. These experiments therefore throw doubt on the chemical theory of neuromuscular transmission.

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Authors and Affiliations

  1. From the Department of Physiology, Medical College, Agra

    Inderjit Singh F.A.Sc., F.N.I., Shakuntala Sharma & O. P. Bhatnagar

Authors
  1. Inderjit Singh F.A.Sc., F.N.I.
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  2. Shakuntala Sharma
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  3. O. P. Bhatnagar
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Singh, I., Sharma, S. & Bhatnagar, O.P. Some evidence against the chemical theory of neuromuscular transmission. Proc. Indian Acad. Sci. 49, 369–376 (1959). https://doi.org/10.1007/BF03053872

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  • DOI: https://doi.org/10.1007/BF03053872

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