Summary
1. The vagus nerves of the frog’s heart were stimulated in 26 experiments. In 11 experiments, there was no detectable release of acetylcholine; in 15 there was release in variable amounts.
2. Direct electrical stimulation caused release of acetylcholine in all the 26 experiments, in amounts greater than that released by nervous stimulation after the fatigue of the vagus nerves, and also in those experiments in which the stimulation of the vagus nerves did not show any detectable release of acetylcholine. It is concluded, therefore, that the acetylcholine liberated on stimulation of the vagus nerves comes from the heart muscle cells and not the nerve endings.
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—————..Ind. Journ. Physiol. and All. Sci., 1959c,13, 31.
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Singh, I., Singh & Bhatnagar, O.P. Source of acetylcholine in the Frog’s heart on stimulation of the vagus nerve. Proc. Indian Acad. Sci. 51, 52–55 (1960). https://doi.org/10.1007/BF03050268
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DOI: https://doi.org/10.1007/BF03050268