Summary
1. The action of lead on the excitatory and contractile mechanism of smooth muscle is described. The latter has been determined by testing the effect of lead on dying and heat killed muscles.
2. Lead causes contraction of smooth muscle and arterioles by direct action on the contractile mechanism. This action may be of significance in producing contraction of smooth muscle in the body and in producing hypertension.
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Aub, J. C., Fairhall, L. T., Minot, A. S. and Reznikoff, P.Medicine, 1925,4, 1. Quoted from W. T. Salter,A Text Book of Pharmacology, W. B. Saunders, London, 1953, p. 983.
Grünberg, F. W...Ztschr. f. d. ges. exper. Med., 1928,62, 649. Quoted from Salter.
Singh, S. I. and Singh, I...Proc. Ind. Acad. Sci., 1946,23, 301.
—————.. Ibid., 1949,30, 270.
—————.. Ibid., 1950,32, 12.
—————.. Ibid., 1954b,40, 125.
—————.. Ibid., 1954c,40, 145.
—————.. Ibid., 1955a,41, 183.
----- ..Ibid., 1955b,42.
----- ..Ibid., 1955c,42.
----- ..Ibid., 1955d,42.
—————..Curr. Sci., 1954a,23, 126.
Sollmann, T...A Manual of Pharmacology, 7th edition, 1948, p. 989, W. B. Saunders, London.
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Singh, S.I., Singh, I. The action of lead on unstriated muscle and blood vessels and its relation to hypertension. Proc. Indian Acad. Sci. 43, 62–66 (1956). https://doi.org/10.1007/BF03050220
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DOI: https://doi.org/10.1007/BF03050220